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Planta medica

An antifungal naphthoquinone, xanthones and secoiridoids from Swertia calycina.


PMID 7480185

Abstract

A chemical and biological screening of 25 species of the Gentianaceae family has been undertaken. Both methanolic and dichloromethane extracts of Swertia calycina exhibited a strong antifungal activity against Cladosporium cucumerinum and Candida albicans. The compound responsible for this activity has been isolated and identified as 2-methoxy-1,4-naphthoquinone. It is the first naphthoquinone to be described in Gentianaceae species. LC-UV and LC-TSP-MS analysis of the crude extracts of Swertia calycina also allowed on-line identification of six known xanthones and secoiridoids.

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189162
2-Methoxy-1,4-naphthoquinone, 98%
C11H8O3