EMAIL THIS PAGE TO A FRIEND

Journal of neurochemistry

gamma-Glutamylglutamine and taurine concentrations are decreased in the cerebrospinal fluid of drug-naive patients with schizophrenic disorders.


PMID 7595563

Abstract

HPLC and gas chromatography-mass spectrometry analyses of 18 amino acids, N-acetylaspartate, N-acetylaspartylglutamate, and 5-hydroxyindoleacetic acid, derived from serotonin, and homovanillic acid, derived from dopamine, were performed in CSF collected from a group of patients with schizophrenia who either had been drug free for at least 1 year (n = 5) or were drug naive for psychotropic drugs (n = 21) and in 15 control subjects. Significant differences were found only for taurine (15% lower in the patients) and isoleucine (7% higher). A number of unidentified substances were detected, one of which proved to be markedly reduced (16%) among the schizophrenic patients. Liquid chromatography-mass spectrometry with continuous flow-fast atom bombardment interface allowed us to identify this substance as gamma-glutamylglutamine. The decreased level of gamma-glutamylglutamine may reflect a deficiency in the gamma-glutamyltransferase system, a system probably involved in glutamate uptake, or a deficiency in glutamine, an important precursor of releasable glutamate. Although glutamate was nonsignificantly reduced in the patients, it was one of the five substances (including gamma-glutamylglutamine) that were necessary for the best discrimination between the schizophrenic patients and the controls. These findings support the notion that the glutamatergic system is affected in schizophrenic disorders. In addition, they underscore the need to apply rigid bioanalytical techniques and use drug-naive patients to gain in-depth information on the pathophysiology of brain disorders such as schizophrenia.

Related Materials

Product #

Image

Description

Molecular Formula

Add to Cart

H50004
4-Hydroxyphenylacetic acid, 98%
C8H8O3
G1001
D-Glutamic acid, ≥99% (TLC)
C5H9NO4
67419 Glycine 1 M solution
02711
Hydroxypyruvic acid phosphate lithium salt, ≥95% (HPLC)
C3H5O7P · xLi+
44526
L-Alanine, certified reference material, TraceCERT®
C3H7NO2
PHR1110
L-Alanine, Pharmaceutical Secondary Standard; Certified Reference Material
C3H7NO2
A0884
L-Asparagine, ≥98% (HPLC)
C4H8N2O3
A4159
L-Asparagine, BioReagent, suitable for cell culture, suitable for insect cell culture
C4H8N2O3
51363
L-Asparagine, certified reference material, TraceCERT®
C4H8N2O3
PHR1104
L-Aspartic acid, Pharmaceutical Secondary Standard; Certified Reference Material
C4H7NO4
51572
L-Aspartic acid, certified reference material, TraceCERT®
C4H7NO4
C7629
L-Citrulline, ≥98% (TLC)
C6H13N3O3
G2150
L-Glutamine solution, 200 mM, Hybri-Max, sterile-filtered, suitable for hybridoma
39496
L-Methionine, certified reference material, TraceCERT®
C5H11NO2S
PHR1241
L-Methionine, Pharmaceutical Secondary Standard; Certified Reference Material
C5H11NO2S
40541
L-Phenylalanine, certified reference material, TraceCERT®
C9H11NO2
91331
L-Phenylalanine, analytical standard, for Nitrogen Determination According to Kjeldahl Method
C9H11NO2
PHR1100
L-Phenylalanine, Pharmaceutical Secondary Standard; Certified Reference Material
C9H11NO2
54763
L-Serine, certified reference material, TraceCERT®
C3H7NO3
PHR1103
L-Serine, Pharmaceutical Secondary Standard; Certified Reference Material
C3H7NO3
59202C
L-Glutamine Solution 200 mM, 29.23 mg/mL in saline, solution, suitable for cell culture
00920
N-Acetyl-L-aspartic acid, ≥99.0% (T)
C6H9NO5
A5930
N-Acetyl-Asp-Glu, ≥97% (TLC), powder
C11H16N2O8