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Parasitology research

In vivo metabolism of aminopyrine by the larvae of the helminth Heligmosomoides polygyrus.


PMID 7624287

Abstract

The in vivo N-dealkylation of [13C-2]-labeled aminopyrine by the L1-L2 larvae of Heligmosomoides polygyrus was demonstrated by the use of a sensitive gas chromatography-mass spectrometry method. This is the first evidence for the possible existence of a cytochrome P-450-dependent activity in helminths.

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