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The Journal of antibiotics

Synthesis of 3-episiastatin B analogues having anti-influenza virus activity.


PMID 8294247

Abstract

Two epimers of siastatin B, 3-episiastatin B (3) and 3,4-diepisiastatin B (4), were obtained by the chemical modification of siastatin B. Compound 3 showed marked inhibitory activity against influenza virus neuraminidases and significant inhibition of influenza virus infection in vitro.

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S8063
Siastatin B, lyophilized powder, from microbial
C8H14N2O5