EMAIL THIS PAGE TO A FRIEND

FEBS letters

Properties of alpha 1-antitrypsin secreted by human adenocarcinoma cell lines.


PMID 8348978

Abstract

alpha 1-Antitrypsin; (alpha 1-AT) produced by various human carcinoma (non-hepatoma) cell lines were analyzed. Five out of eight cell lines secreted detectable amounts of alpha 1-AT into the conditioned media. All were adenocarcinoma cell lines. The tumor cell-derived alpha 1-ATs had higher molecular weights (MW) than the normal plasma form. Most of this difference was an overall reflection of altered N-glycosylation. As judged by binding of lectins, the glycosylation had shifted towards higher levels of triantennary oligosaccharides and higher levels of fucosylation. The conditioned media also contained lower MW alpha 1-AT species, possibly, proteolytically cleaved forms.

Related Materials

Product #

Image

Description

Molecular Formula

Add to Cart

details
LC-2/ad, 94072247