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Eksperimental'naia i klinicheskaia farmakologiia

[The mechanisms of the thermal protective action of atsefen].


PMID 8704597

Abstract

The study of thermoprotective properties of acephen (300 mg, single dosage) showed an increase (compared to that of placebo) in the maximum endurable time under thermal loading in healthy volunteers: optimization of evaporative heat exchange regime; reduction of the final values of reactive anxiety and fatigue and decrease in the rate of skin temperature growth. In combination with the data of biochemical analysis of peripheral blood which demonstrated positive changes in hormone, lipid, protein, and energy metabolism as well as in vegetative regulation, the results testify to a substantial thermoprotective potential of acephen attributed to the wide range of its pharmacological activity.