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Planta medica

Active constituents against HIV-1 protease from Garcinia mangostana.


PMID 8792678

Abstract

The ethanol extract of Garcinia mangostana L. (Guttiferae) showed potent inhibitory activity against HIV-1 protease. The activity-guided purification of the extract resulted in the isolation of two active, known compounds. The chemical structures of the isolated compounds were established by spectroscopic analyses as mangostin (IC50 = 5.12 +/- 0.41 microM) and gamma-mangostin (IC50 = 4.81 +/- 0.32 microM). The type of inhibition by both compounds is noncompetitive.

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M6824
gamma-Mangostin, ≥98% (HPLC)
C23H24O6