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Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

Increases in rates of resistance to trimethoprim.


PMID 8994780

Abstract

Trimethoprim alone or in combination with a sulfonamide is an effective and relatively inexpensive antibacterial medication. However, a dramatic increase in the rate of resistance to trimethoprim along with high-level resistance to sulfonamides has been seen during the past two decades. The mechanisms of resistance show a remarkable evolutionary adaptation.