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Journal of chromatographic science

Mefanamic acid blood and urine levels in the horse determined by derivative gas-liquid chromatography-electron capture.


PMID 943417

Abstract

Mefenamic acid is extracted from biological fluids and is acylated with pentafluoropropionic anhydride to form a derivative possessing high electron affinity. The derivative is analyzed by gas-liquid chromatography with an electron capture detector. The method is particularly valuable for determining drug levels in blood where small sample and/or drug concentrations are available.

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Pentafluoropropionic anhydride
C6F10O3