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Nucleic acids symposium series

Synthesis of DHPA analogs and their inhibitory activities of human recombinant S-adenosyl-L-homocysteine hydrolase.


PMID 9585974

Abstract

We report syntheses of DHPA analogs, e.g., 9-(3-formyl-2,3-dihydroxypropyl)adenine (FDHPA) and 9-(3-formyl-2,3-dihydroxypropyl)hypoxanthine (FDHPI). Among these DHPA analogs, FDHPA behaved as an irreversible inactivator of human recombinant SAH hydrolase.