EMAIL THIS PAGE TO A FRIEND

Science (New York, N.Y.)

Death receptors: signaling and modulation.


PMID 9721089

Abstract

Apoptosis is a cell suicide mechanism that enables metazoans to control cell number in tissues and to eliminate individual cells that threaten the animal's survival. Certain cells have unique sensors, termed death receptors, on their surface. Death receptors detect the presence of extracellular death signals and, in response, they rapidly ignite the cell's intrinsic apoptosis machinery.