EMAIL THIS PAGE TO A FRIEND

Journal of pharmaceutical and biomedical analysis

Spectrofluorimetric determination of prenalterol hydrochloride in pharmaceutical preparations and biological fluids.


PMID 9925334

Abstract

A simple and highly sensitive fluorimetric method was developed for the routine determination of prenalterol hydrochloride in bulk, in dosage forms and in biological fluids. The method is based on the fluorescence induced by reaction of the nitroso-derivative of prenalterol hydrochloride with 2-cyanoacetamide in the presence of ammonia. The different experimental parameters were carefully studied and incorporated into the procedure. The fluorescence is measured at 440 nm after excitation at 368 nm. Fluorescence intensity is a linear function of prenalterol hydrochloride concentration over the range of 0.1-2.8 microg x ml(-1) in the solution finally measured. A proposal for the reaction pathway was suggested.

Related Materials

Product #

Image

Description

Molecular Formula

Add to Cart

108448
Cyanoacetamide, 99%
C3H4N2O