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109185 Sigma-Aldrich

Saccharin

≥98%

Synonym: 2,3-Dihydroxy-1,2-benzisothiazol-3-one-1,1-dioxide, 2-Sulfobenzoic acid imide, o-Benzoic sulfimide

  • CAS Number 81-07-2

  • Empirical Formula (Hill Notation) C7H5NO3S

  • Molecular Weight 183.18

  •  Beilstein/REAXYS Number 6888

  •  EC Number 201-321-0

  •  MDL number MFCD00005866

  •  PubChem Substance ID 24846892

  •  NACRES NA.22

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Properties

Related Categories Building Blocks, C3 to C7, Chemical Synthesis, Heterocyclic Building Blocks, Thiazoles More...
Quality Level   100
assay   ≥98%
mp   226-229 °C (lit.)
solubility   H2O: soluble 1g in 290ml
  acetone: soluble 1g in 12ml
  alcohol: soluble 1g in 31ml
  boiling water: soluble 1g in 25ml
  glycerol: soluble 1g in 50ml
  alcohol: very slightly soluble
  chloroform: slightly soluble
  diethyl ether: slightly soluble
SMILES string   O=C1NS(=O)(=O)c2ccccc12
InChI   1S/C7H5NO3S/c9-7-5-3-1-2-4-6(5)12(10,11)8-7/h1-4H,(H,8,9)
InChI key   CVHZOJJKTDOEJC-UHFFFAOYSA-N

Description

Application

Saccharin was used in high performance liquid chromatographic method for the simultaneous separation and determination of acesulfame potassium, saccharine and aspartame. It was used in sweet preference test of rats.

Packaging

250, 500 g in poly bottle

Biochem/physiol Actions

Dietery administration of saccharin after N-methyl-N′-nitro-N-nitrosoguanidine promotes tumor development in rats.

A sweet tastant for mammals. A glycerol taste receptor binding site specific for glucose has been proposed in drosophila.

Safety & Documentation

Safety Information

Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 2
RTECS 
DE4200000
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Certificate of Origin (COO)

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Protocols & Articles
Peer-Reviewed Papers
15

References

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