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167398 Sigma-Aldrich

tert-Butyl carbamate

98%

Synonym: Boc-amide

  • CAS Number 4248-19-5

  • Linear Formula NH2COOC(CH3)3

  • Molecular Weight 117.15

  •  Beilstein/REAXYS Number 1744500

  •  EC Number 224-209-3

  •  MDL number MFCD00007962

  •  PubChem Substance ID 24850207

  •  NACRES NA.22

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Properties

Related Categories Building Blocks, Chemical Synthesis, Nitrogen Compounds - Organic Building Blocks, Organic Building Blocks, Protected Amines More...
Quality Level   200
assay   98%
mp   105-108 °C (lit.)
SMILES string   CC(C)(C)OC(N)=O
InChI   1S/C5H11NO2/c1-5(2,3)8-4(6)7/h1-3H3,(H2,6,7)
InChI key   LFKDJXLFVYVEFG-UHFFFAOYSA-N

Description

General description

Palladium-catalyzed cross-coupling reaction of tert-butyl carbamate with various aryl(Het) halides with Cs2CO3 as base in 1,4-dioxane (solvent) has been investigated.

Application

tert-Butyl carbamate was used in palladium-catalyzed synthesis of N-Boc-protected anilines. It was used in the synthesis of tetrasubstituted pyrroles, functionalized with ester or ketone groups at C-3 position.

Packaging

1, 5, 25, 100 g in glass bottle

Safety & Documentation

Safety Information

Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable
Protocols & Articles

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Lab Chemicals

From our library of Related Content, Sigma-Aldrich presents Lab Chemicals
Keywords: Gas chromatography, Infrared spectroscopy, Sublimation, Thin layer chromatography

Peer-Reviewed Papers
15

References

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