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189901 Sigma-Aldrich

Methylmagnesium chloride solution

3.0 M in THF

  • CAS Number 676-58-4

  • Linear Formula CH3MgCl

  • Molecular Weight 74.79

  •  Beilstein/REAXYS Number 3587199

  •  MDL number MFCD00000468

  •  PubChem Substance ID 24851404

  •  NACRES NA.22



Related Categories 25mL Sure/Seal Reagents, Acids & Bases, Alkyl, Aryl and Alkenyl - Grignard reagent, Bases, Chemical Synthesis,
Quality Level   200
autoignition temp.   609 °F
concentration   3.0 M in THF
density   1.013 g/mL at 25 °C
SMILES string   C[Mg]Cl
InChI   1S/CH3.ClH.Mg/h1H3;1H;/q;;+1/p-1



Methylmagnesium chloride solution (3 M in THF) undergoes 1,3-addition with dialdose derived nitrones to form N-benzylhydroxylamines. The reductive cleavage of the N-O bond of these N-benzylhydroxylamines results in N-benzylaminosugars, which are key moieties of bioactive compounds. It can also react with Garner type aldehydes to form the corresponding secondary alcohols.


4×25, 100, 800 mL in Sure/Seal™

8, 18 L in Kilo-Lab™

The 25 mL Sure/Seal bottle is recommended as a single-use bottle. Repeated punctures will likely result in decreased performance of product.

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Legal Information

Sure/Seal is a trademark of Sigma-Aldrich Co. LLC

Safety & Documentation

Safety Information

Signal word 
Hazard statements 
Supplemental Hazard Statements 
May form explosive peroxides., Reacts violently with water.
UN 3399BC 4.3(3) / PGII
WGK Germany 
Flash Point(F) 
1.4 °F
Flash Point(C) 
-17 °C


Certificate of Analysis (COA)

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Certificate of Origin (COO)

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Frequently Asked Questions

Which document(s) contains shelf-life or expiration date information for a given product?
If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.
How do I get lot-specific information or a Certificate of Analysis?
The lot specific COA document can be found by entering the lot number above under the "Documents" section.
How do I find price and availability?
There are several ways to find pricing and availability for our products.Once you log onto our website, you will find the price and availability displayed on the product detail page.You can contact any of our Customer Sales and Service offices to receive a quote. USA customers: 1-800-325-3010 orview local office numbers.
What is the Department of Transportation shipping information for this product?
Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.
Is the BHT inhibitor present in Product 189901, Methylmagnesium chloride solution?
Yes, BHT is present in the THF. This information can be found on the MSDS, which is available from our website.
Can Product 189901, Methylmagnesium chloride solution, be used if a precipitate is present?
If a precipitate is present, the product can be heated and stirred until the precipitate is dissolved.
My question is not addressed here, how can I contact Technical Service for assistance?
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