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199915 Sigma-Aldrich

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine

97%

Synonym: MPTP

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Properties

Related Categories Building Blocks, C12, Chemical Synthesis, Heterocyclic Building Blocks, Pyridines More...
assay   97%
drug control   regulated under CDSA - not available from Sigma-Aldrich Canada
bp   128-132 °C/12 mmHg (lit.)
SMILES string   CN1CCC(=CC1)c2ccccc2
InChI   1S/C12H15N/c1-13-9-7-12(8-10-13)11-5-3-2-4-6-11/h2-7H,8-10H2,1H3
InChI key   PLRACCBDVIHHLZ-UHFFFAOYSA-N

Description

Biochem/physiol Actions

Dopaminergic neurotoxin.

Warning

Reportedly causes a severe and irreversible Parkinsonism condition in humans and monkeys. New Engl. J. Med. 1983, 309, 310. Science 1983, 219, 979. ibid. 1984, 224, 1083, 1451. ibid. 1984, 225, 529. J. Med. Chem. 1985, 28, 997.

Safety & Documentation

Safety Information

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Peer-Reviewed Papers
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References

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