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247685 Sigma-Aldrich

2-Fluoro-6-nitrotoluene

98%

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Properties

Related Categories Aryl Fluorinated Building Blocks, Building Blocks, C7, Chemical Synthesis, Fluorinated Building Blocks,
Quality Level   100
assay   98%
refractive index   n20/D 1.523 (lit.)
bp   97 °C/11 mmHg (lit.)
mp   6.5-7 °C (lit.)
density   1.27 g/mL at 25 °C (lit.)
SMILES string   Cc1c(F)cccc1[N+]([O-])=O
InChI   1S/C7H6FNO2/c1-5-6(8)3-2-4-7(5)9(10)11/h2-4H,1H3
InChI key   GXPIVRKDWZKIKZ-UHFFFAOYSA-N

Description

General description

2-Fluoro-6-nitrotoluene undergoes reduction in the presence of stannous chloride, followed by benzoylation to yield N-(3-fluoro-o-tolyl)benzamide. 2-Fluoro-6-nitrotoluene undergoes reaction with concentrated nitric acid at 100°C to yield 2-fluoro-6-nitrobenzoic acid.

Application

2-Fluoro-6-nitrotoluene has been used in the preparation of 4-fluoroindole via Leimgruber-Batcho procedure.

Packaging

10 g in glass bottle

Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Target organs 
Respiratory system
WGK Germany 
WGK 3
Flash Point(F) 
192.2 °F - closed cup
Flash Point(C) 
89 °C - closed cup
Protocols & Articles
Peer-Reviewed Papers
15

References

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