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264423 Sigma-Aldrich

2,5-Difluorobenzyl bromide

98%

Synonym: α-Bromo-2,5-difluorotoluene

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Properties

Related Categories Aryl, Aryl Fluorinated Building Blocks, Building Blocks, C7, Chemical Synthesis,
Quality Level   100
assay   98%
refractive index   n20/D 1.526 (lit.)
density   1.609 g/mL at 25 °C (lit.)
SMILES string   Fc1ccc(F)c(CBr)c1
InChI   1S/C7H5BrF2/c8-4-5-3-6(9)1-2-7(5)10/h1-3H,4H2
InChI key   ONWGSWNHQZYCFK-UHFFFAOYSA-N

Description

Application

2,5-Difluorobenzyl bromide has been used in the synthesis of:
• novel series of 4-aryl, 4-phenylsulfonyl cyclohexananone-derived γ-secretase inhibitors, for the potential treatment of Alzheimer′s disease
• sulfonamide, amide and acyclic amine derivatives

Packaging

1, 10 g in glass bottle

Safety & Documentation

Safety Information

Symbol 
Signal word 
Danger
Hazard statements 
Precautionary statements 
RIDADR 
UN 2924 8(3) / PGII
WGK Germany 
WGK 3
Flash Point(F) 
60.8 °F - closed cup
Flash Point(C) 
16 °C - closed cup
Protocols & Articles
Peer-Reviewed Papers
15

References

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