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379395 Sigma-Aldrich

Ethyl 1-piperidineacetate

98%

Synonym: Piperidin-1-ylacetic acid ethyl ester

  • CAS Number 23853-10-3

  • Empirical Formula (Hill Notation) C9H17NO2

  • Molecular Weight 171.24

  •  MDL number MFCD00134496

  •  PubChem Substance ID 24863628

  •  NACRES NA.22

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Properties

Related Categories Building Blocks, C9, Chemical Synthesis, Heterocyclic Building Blocks, Piperidines More...
Quality Level   100
assay   98%
refractive index   n20/D 1.453 (lit.)
bp   109-111 °C/25 mmHg (lit.)
density   0.984 g/mL at 25 °C (lit.)
SMILES string   CCOC(=O)CN1CCCCC1
InChI   1S/C9H17NO2/c1-2-12-9(11)8-10-6-4-3-5-7-10/h2-8H2,1H3
InChI key   LXZHLNWWDDNIOJ-UHFFFAOYSA-N

Description

General description

Ethyl 1-piperidineacetate (Piperidin-1-ylacetic acid ethyl ester) is an α-amino acid ethyl ester derivative. Thermal decomposition of ethyl 1-piperidineacetate in gas phase has been studied by ab initio theoretical methods. The kinetics of gas-phase decomposition of ethyl 1-piperidineacetate to the corresponding α-amino acid derivative and ethylene over the temperature range of 360-430°C and pressure range of 26-86Torr has been investigated. Alkylation reaction of ethyl 1-piperidineacetate with ethyl bromoacetate in absolute ethanol has been reported to obey second order kinetics.

Application

Reactant for synthesis of:
Nicotinic acid receptor agonists for treatment of dyslipidemia
1-Alkylcyclanols with side chain functions
Benzhydrylamides for pharmacochemical studies

Reactant for:
Elimination reactions
Hydrogenation of esters to alcohols

Packaging

5 mL in glass bottle

Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
Precautionary statements 
Target organs 
Respiratory system
WGK Germany 
WGK 3
Flash Point(F) 
195.8 °F - closed cup
Flash Point(C) 
91 °C - closed cup
Protocols & Articles
Peer-Reviewed Papers
15

References

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