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394882 Sigma-Aldrich

N-tert-Butyldimethylsilyl-N-methyltrifluoroacetamide

>97%

Synonym: MTBSTFA

  • CAS Number 77377-52-7

  • Linear Formula CF3CON(CH3)Si(CH3)2C(CH3)3

  • Molecular Weight 241.33

  •  Beilstein/REAXYS Number 3606546

  •  MDL number MFCD00009671

  •  PubChem Substance ID 24864624

  •  NACRES NA.22

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Properties

Related Categories Amides, Analytical Reagents, Analytical/Chromatography, Biochemicals and Reagents, Chemical Synthesis,
Quality Level   200
grade   derivatization grade
assay   >97%
refractive index   n20/D 1.402 (lit.)
bp   172-175 °C (lit.)
density   1.036 g/mL at 25 °C (lit.)
storage temp.   2-8°C
SMILES string   CN(C(=O)C(F)(F)F)[Si](C)(C)C(C)(C)C
InChI   1S/C9H18F3NOSi/c1-8(2,3)15(5,6)13(4)7(14)9(10,11)12/h1-6H3
InChI key   QRKUHYFDBWGLHJ-UHFFFAOYSA-N

Description

Application

N-tert-butyldimethylsilyl-N-methyltrifluoroacetamide (MTBSTFA) can be used as an efficient silylating agent for different alcohols, thiols, phenols, carboxylic acids, amines, and amides. It can also be used to functionalize multi-walled carbon nanotubes (MWCNTs) with polar groups. MTBSTFA is reportedly much less moisture-sensitive than other silylating reagents used for GLC derivatization.

Packaging

10×1 mL in ampule

5, 25, 100 mL in glass bottle

Safety & Documentation

Safety Information

Symbol 
GHS02  GHS02
Signal word 
Warning
Hazard statements 
Precautionary statements 
RIDADR 
UN 1993C 3 / PGIII
WGK Germany 
WGK 3
Flash Point(F) 
113.0 °F - closed cup
Flash Point(C) 
45 °C - closed cup
Protocols & Articles

Articles

Silylating Reagents for GC-MS Compatible Derivatives of NSAIDs

Human and veterinary pharmaceuticals are a group of “emerging” contaminants,1, 2 some of which are produced in increasingly large volumes every year. The amounts produced are reaching quantities simi...
Luis-Alberto Martin
AnalytiX Volume 10 Article 2
Keywords: Anti-inflammatory agents, Derivatizations, Environmental, Gas chromatography, Gas chromatography mass spectrometry, Mass spectrometry, Metabolites, Pesticides, Pharmaceutical, Silylations, Veterinary

Peer-Reviewed Papers
15

References

Related Products

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Product #

Description

Add to Cart

190500 tert-Butyldimethylsilyl chloride, reagent grade, 97%
375934 N-tert-Butyldimethylsilyl-N-methyltrifluoroacetamide with 1% tert-Butyldimethylchlorosilane, ≥95%
473464 tert-Butylchlorodimethylsilane solution, 50 wt. % in toluene
384429 tert-Butyldimethylsilyl chloride solution, 1.0 M in methylene chloride
372951 tert-Butyldimethylsilyl chloride solution, 1.0 M in THF
226149 tert-Butyldimethylsilyl trifluoromethanesulfonate, reagent grade, 98%
250236 1-(tert-Butyldimethylsilyl)imidazole, ≥95%
06735 tert-Butyldimethylsilyl chloride, for GC derivatization, LiChropur, ≥99.0% (GC)
56563 tert-Butyldimethylsilyl trifluoromethanesulfonate, for GC derivatization, LiChropur, ≥98.0% (T)
77626 N-tert-Butyldimethylsilyl-N-methyltrifluoroacetamide, for GC derivatization, LiChropur, ≥99.0% (GC)
00942 N-tert-Butyldimethylsilyl-N-methyltrifluoroacetamide with 1% tert-Butyldimethylchlorosilane, for GC derivatization, LiChropur, ≥95.0% (GC)
44795 N,O-Bis(tert-butyldimethylsilyl)acetamide, for GC derivatization, LiChropur, ≥98.0% (GC)
08168 Timestrip Plus 8 °C

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