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415936 Sigma-Aldrich

3,4-Dihydro-2(1H)-quinolinone

98%

Synonym: Hydrocarbostyril

  • CAS Number 553-03-7

  • Empirical Formula (Hill Notation) C9H9NO

  • Molecular Weight 147.17

  •  MDL number MFCD00016722

  •  PubChem Substance ID 24866044

  •  NACRES NA.22

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Properties

Related Categories Building Blocks, C8 to C10, Chemical Synthesis, Heterocyclic Building Blocks, Quinolines More...
Quality Level   100
assay   98%
mp   165-167 °C (lit.)
SMILES string   O=C1CCc2ccccc2N1
InChI   1S/C9H9NO/c11-9-6-5-7-3-1-2-4-8(7)10-9/h1-4H,5-6H2,(H,10,11)
InChI key   TZOYXRMEFDYWDQ-UHFFFAOYSA-N

Description

General description

Series of 3,4-dihydro-2(1H)-quinolinone derivatives having sigma-1 receptor (σ1R) antagonist activity have been synthesized. 3,4-dihydro-2((1)H)-quinolinones have been synthesized using N-(1′-alkoxy)cyclopropyl-2-haloanilines as starting reagent. Cyclopropane ring expansion in the presence of palladium catalyst is the major step involved in the synthesis. Library of 3,4-dihydro-2(1H)-quinolinones have been synthesized through the rearrangement of β-lactam intermediates on the solid-phase

Application

3,4-Dihydro-2(1H)-quinolinone may be employed as medium supplement in the culture medium of Pseudomonas ayucida during enrichment culture experiments.

Packaging

1, 10 g in glass bottle

Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
Precautionary statements 
RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis (COA)

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Protocols & Articles
Peer-Reviewed Papers
15

References

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