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439479 Aldrich

Selectfluor® fluorinating reagent Green Alternative

>95% in F+ active

Synonym: 1-Chloromethyl-4-fluoro-1,4-diazoniabicyclo[2.2.2]octane bis(tetrafluoroborate), N-Chloromethyl-N′-fluorotriethylenediammonium bis(tetrafluoroborate), F-TEDA

  • CAS Number 140681-55-6

  • Empirical Formula (Hill Notation) C7H14B2ClF9N2

  • Molecular Weight 354.26

  •  Beilstein Registry Number 5368649

  •  MDL number MFCD00142607

  •  PubChem Substance ID 24867509

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Properties

Related Categories 12 Principles Aligned Products, C-H Activation, Catalysis and Inorganic Chemistry, Chemical Synthesis, Fluorination,
InChI Key   TXRPHPUGYLSHCX-UHFFFAOYSA-N
greener alternative product characteristics   Catalysis
Learn more about the Principles of Green Chemistry.
concentration   >95% in F+ active
mp   260 °C(lit.)
storage temp.   2-8°C

Description

Packaging

5, 25, 100 g in poly bottle

Application

Electrophilic fluorinating reagent used for greener fluorination of acetoacetamides in PEG-400.
Catalyst-free and highly selective electrophilic mono-fluorination of acetoacetamides: facile and efficient preparation of 2-fluoroacetoacetamides in PEG-400

General description

Sigma Life Science is committed to bringing you Greener Alternative Products, which adhere to one or more of The 12 Principles of Greener Chemistry. This product has been enhanced for energy efficiency. Find details here.

Citation

A review.

Safety & Documentation

Safety Information

Symbol 
Signal word 
Danger
Hazard statements 
Precautionary statements 
Personal Protective Equipment 
RIDADR 
UN 3088 4.2 / PGII
WGK Germany 
2

Screeing simplified
Protocols & Articles

Articles

Fluorinating Reagents

The importance of selectively fluorinating compounds in medicinal chemistry, biology, and organic synthesis is well appreciated and provides a major impetus to the discovery of new and mild fluorinat...
Aldrich ChemFiles 2006, 6.2, 5.
Keywords: Fluorinations, Medicinal chemistry, Metathesis, Organic synthesis

Reagents for Fluorination

The trifluoromethyl substituent has long been recognized for the positive influence it can have on the biological activity of molecules. Professor William Dolbier, Jr. (University of Florida) has dev...
Aldrich ChemFiles 2007, 7.1, 11.

Peer-Reviewed Papers
15

References

Related Products

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