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  • 440167 - (3-Glycidyloxypropyl)trimethoxysilane

440167 Sigma-Aldrich



Synonym: 3-(2,3-Epoxypropoxy)propyltrimethoxysilane, GLYMO, Glycidyl 3-(trimethoxysilyl)propyl ether

  • CAS Number 2530-83-8

  • Empirical Formula (Hill Notation) C9H20O5Si

  • Molecular Weight 236.34

  •  Beilstein/REAXYS Number 4308125

  •  EC Number 219-784-2

  •  MDL number MFCD00005144

  •  PubChem Substance ID 24867573

  •  NACRES NA.23



Related Categories Chemical Synthesis, Materials Science, Micro/NanoElectronics, Organometallic Reagents, Organosilicon,
Quality Level   200
assay   ≥98%
form   liquid
refractive index   n20/D 1.429 (lit.)
bp   120 °C/2 mmHg (lit.)
density   1.07 g/mL at 25 °C (lit.)
storage temp.   room temp
InChI   1S/C9H20O5Si/c1-10-15(11-2,12-3)6-4-5-13-7-9-8-14-9/h9H,4-8H2,1-3H3


General description

(3-Glycidyloxypropyl)trimethoxysilane (GPTMS) is a bifunctional organosilane with three methoxy groups on one side and an epoxy ring on the other. The methoxy groups bind well with glass substrates creating a 3D matrix. The epoxy group is reactive with amides, alcohols, thiols and acids. GPTMS is highly reactive in water and can be used as a linking agent between the surface of the silica and the polymeric matrix.


GPTMS is widely used as a silica precursor. GPTMS alone with tetraethylortosilicate (TEOS) can be blended with chitosan for use as a filler for polymeric scaffold for bone tissue engineering. It can also be coated on the surface of aluminium alloy to protect from corrosion. GPTMS can used to functionalize (wrap) multi-walled carbon nanotubes (MWCNTs) which can be used as s a reinforcement in epoxy matrix nanocomposites.

Pre-treatment of carbon steel with 3-(Glycidoxypropyl)trimethoxysilane enhances the dry and wet adhesion while reducing the cathotic disbondment rate of an epoxy coating


1 L in glass bottle

100, 500 mL in Sure/Seal™

Safety & Documentation

Safety Information

GHS05  GHS05
Signal word 
Hazard statements 
Precautionary statements 
NONH for all modes of transport
WGK Germany 
Flash Point(F) 
251.6 °F - Cleveland open cup
Flash Point(C) 
122 °C - Cleveland open cup

Frequently Asked Questions

Which document(s) contains shelf-life or expiration date information for a given product?
If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.
How do I get lot-specific information or a Certificate of Analysis?
The lot specific COA document can be found by entering the lot number above under the "Documents" section.
IsProduct 440167 (3-Glycidyloxypropyl)trimethoxysilane GLYMO, equivalent to Dow's Z-6040?
Yes. This listing is manufactured by Dow Corning Corporation and distributed by Sigma-Aldrich.
What can Product 440167, 3-Glycidyloxypropyl)trimethoxysilane GLYMO, be used for?
According to Dow Corning®, 3-GLYCIDOXYPROPYLTRIMETHOXYSILANE can be used as a coupling agent for many thermoset resins with glass or mineral fillers. Specifically, it has been used as a reinforcement treatment on glass fiber to improve physical properties (especially wet strength) or as an adhesion promoter to improve the bonding of a polymer coating or adhesive to glass, metals or other polymeric surfaces.
What is the viscosity of Product 440167 (3-Glycidyloxypropyl)trimethoxysilane GLYMO?
This material is a low viscosity liquid with an average value of about 3 centistokes. Please note that this value is not part of our specifications.
Where can I find products similar to Product 440167 (3-Glycidyloxypropyl)trimethoxysilane GLYMO?
Other tri-alkoxy and greater silanes similar to product 440167 can be found at this link.
Where can I find more detailed information about how to use Product 440167. 3-Glycidyloxypropyl)trimethoxysilane, GLYMO, in adhesion/reinforcement applications?
Dow Corning® has published a technical bulletin on this product, which is available by calling Technical Service at 800-231-8327.
How do I find price and availability?
There are several ways to find pricing and availability for our products. Once you log onto our website, you will find the price and availability displayed on the product detail page. You can contact any of our Customer Sales and Service offices to receive a quote. USA customers: 1-800-325-3010 or view local office numbers.
What is the Department of Transportation shipping information for this product?
Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.
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Protocols & Articles


Synthesis of Melting Gels Using Mono-Substituted and Di-Substituted Alkoxysiloxanes

Hybrid organic-inorganic sol-gel materials containing silica were first called “ORMOSILs” in 1984.1 Since then, the number of hybrid organicinorganic combinations has increased rapidly.2 Hybrid mater...
Lisa C. Klein and Andrei Jitianu
Material Matters, Volume 7, Number 2, 8–14
Keywords: Absorption, Adhesion, Calorimetry, Combustion, Condensations, Deposition, Exothermic, Filtration, Materials Science, Melting, Oxidations, Polymerization reactions, Purification, Semiconductor, Sol-gel, Solar cells, Solvents, Spin coating, Substitutions, Thermal analysis

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