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462128 Sigma-Aldrich

6-Methylpyridine-2-carboxylic acid

Synonym: 2-Carboxy-6-methylpyridine, 6-Methylpicolinic acid, NSC 109143, NSC 26023

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Properties

Related Categories Building Blocks, C7, Chemical Synthesis, Heterocyclic Building Blocks, Pyridines More...
bp   100 °C/4.5 mmHg (lit.)
mp   120-127 °C (lit.)
SMILES string   Cc1cccc(n1)C(O)=O
InChI   1S/C7H7NO2/c1-5-3-2-4-6(8-5)7(9)10/h2-4H,1H3,(H,9,10)
InChI key   LTUUGSGSUZRPRV-UHFFFAOYSA-N

Description

General description

6-Methylpyridine-2-carboxylic acid (2-carboxy-6-methylpyridine, 6-methylpicolinic acid) is a heterocyclic building block.

Application

6-Methylpyridine-2-carboxylic acid may be used in the preparation of 2-(2-benzoxazolyl)-6-methylpyridine and 1,5-cyclooctadiene iridium(I) complexes bearing chelating ligands.

Pharmacological activity studied in regard to:
• Interactions of carrier ligands of antidiabetic metal complexes with human serum albumin
• Ability to chelate metalloenzyme inhibitors
• Interactions of insulin-mimetic zinc(II) complexes with cell constituents

Reactant for:
• Synthesis of inhibitors of human 11β -hydroxysteroid dehydrogenase type 1
• Lewis base organocatalysts for stereoselective hydrosilylation reactions

Biological studies of insulin-enhancing complexes

Packaging

1, 5 g in glass bottle

Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
Precautionary statements 
Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
3
Protocols & Articles
Peer-Reviewed Papers
15

References

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