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492876 Sigma-Aldrich

L-Alanine-12C3

99.9 atom % 12C

  • CAS Number 56-41-7

  • Linear Formula 12CH312CH(NH2)12CO2H

  • Molecular Weight 89.06

  •  Beilstein/REAXYS Number 1720248

  •  EC Number 200-273-8

  •  MDL number MFCD00198168

  •  PubChem Substance ID 24872786

Note: This product can be packaged on demand. For information on pricing, availability and packaging of custom sizes, please contact Stable Isotopes Customer Service.
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Properties

Related Categories A, Alanine, Alphabetical Listings, Amino Acids & Derivatives, Stable Isotopes More...
Quality Level   200
description   13C-depleted
isotopic purity   99.9 atom % 12C
optical activity   [α]25/D +14.5°, c = 2 in 1 M HCl
availability   available only in Japan
mp   314.5 °C (dec.) (lit.)
mass shift   depleted
SMILES string   [12CH3][12C@H](N)[12C](O)=O
InChI   1S/C3H7NO2/c1-2(4)3(5)6/h2H,4H2,1H3,(H,5,6)/t2-/m0/s1/i1+0,2+0,3+0
InChI key   QNAYBMKLOCPYGJ-BWIFZRRMSA-N

Description

Biochem/physiol Actions

L-Alanine is a nonessential amino acid, which is highly concentrated in muscle. It is a key player in the Glucose-Alanine cycle, which enables the removal of pyruvate and glutamate from muscle to the liver. Once in the liver, glucose is regenerated from pyruvate and returned to the muscle while glutamate ultimately participates in the urea cycle to form urea. The Glucose-Alanine cycle aides to conserve ATP in muscle for muscle contraction, while the energy burden of gluconeogenesis is imposed upon the liver. Alanine inhibits pyruvate kinase to regulate gluconeogenesis and glycolysis in order to maintain glucose homeostasis during starvation. Alanine prevents hepatic autophagy. Alanine formation is a result of transamination of glutamate and pyruvate.

Packaging

This product may be available from bulk stock and can be packaged on demand. For information on pricing, availability and packaging, please contact Stable Isotopes Customer Service.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 1
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Protocols & Articles
Peer-Reviewed Papers
15

References

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