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551902 Sigma-Aldrich

5-Bromo-2-chloropyridine

95%

  • CAS Number 53939-30-3

  • Empirical Formula (Hill Notation) C5H3BrClN

  • Molecular Weight 192.44

  •  MDL number MFCD01318951

  •  PubChem Substance ID 24879237

  •  NACRES NA.22

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Properties

Related Categories Building Blocks, C5, Chemical Synthesis, Halogenated Heterocycles, Heterocyclic Building Blocks,
Quality Level   100
assay   95%
mp   65-69 °C (lit.)
SMILES string   Clc1ccc(Br)cn1
InChI   1S/C5H3BrClN/c6-4-1-2-5(7)8-3-4/h1-3H
InChI key   PEAOEIWYQVXZMB-UHFFFAOYSA-N

Description

Application

5-Bromo-2-chloropyridine may be used in the preparation of following compounds:
• Amino-2-chloropyridine via palladium-catalyzed amination.
• 5-Bromo-2-fluoropyridine via halogen-exchange reaction using anhydrous potassium fluoride.
• 2-Chloro-5-(2,5-dimethoxyphenyl)pyridine via Suzuki coupling with 2,5-dimethoxyphenylboronic acid.

Packaging

5, 25 g in glass bottle

Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
Precautionary statements 
Target organs 
Respiratory system
Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Certificate of Origin (COO)

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Protocols & Articles

Articles

Selective Amination of Polyhalopyridines Catalyzed by a Palladium-Xantphos Complex

Amination of 5-bromo-2-chloropyridine (1a) catalyzed by a palladium-Xantphos complex predominately gives 5-amino-2-chloropyridine product 3a in 96% isolated yield and excellent chemoselectivity (3a/4...
Keywords: Aminations, Catalysis, Chromatography, High performance liquid chromatography

Peer-Reviewed Papers
15

References

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