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74540 Sigma-Aldrich

Nordihydroguaiaretic acid

≥97.0% (HPLC)

Synonym: 1,4-Bis(3,4-dihydroxyphenyl)-2,3-dimethylbutane, 4,4′-(2,3-Dimethyltetramethylene)dipyrocatechol, Masoprocol, NDGA

  • CAS Number 500-38-9

  • Linear Formula [-CH(CH3)CH2C6H3-1,2-(OH)2]2

  • Molecular Weight 302.36

  •  Beilstein/REAXYS Number 2056826

  •  EC Number 207-903-0

  •  MDL number MFCD00002206

  •  PubChem Substance ID 57652455

  •  NACRES NA.22

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Properties

Related Categories Building Blocks, Chemical Synthesis, Organic Building Blocks, Oxygen Compounds, Polyols More...
InChI Key   HCZKYJDFEPMADG-UHFFFAOYSA-N
assay   ≥97.0% (HPLC)
impurities   ≤2% water
mp   184-186 °C (lit.)
Gene Information   mouse ... Alox12(11684)

Description

General description

Nordihydroguaiaretic acid (NDGA) is used as an antioxidant and potent scavenger of reactive oxygen species (ROS).

Application

Nordihydroguaiaretic acid can be used:
• In the synthesis of nordihydroguaiaretic acid derivatives with potent HIV inhibition activity.
• As a starting material in the synthesis of tetra-O-methylnordihydroguaiaretic acid.

Packaging

1, 5 g in glass bottle

Biochem/physiol Actions

Lipoxygenase inhibitor; polyphenol-bearing o-dihydroxy (catechol) structure.

Other Notes

Inhibitor of broad bean lipoxygenase

Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
Precautionary statements 
Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
3
RTECS 
UX1750000

Documents

Certificate of Analysis (COA)

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Protocols & Articles

Articles

HPLC Analysis of Antioxidants on SUPELCOSIL™ LC-18

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Antioxidants on SUPELCOSIL™ LC-18
Keywords: Chromatography, Cosmetics, High performance liquid chromatography

Peer-Reviewed Papers
15

References

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