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760927 Sigma-Aldrich

Poly(ethylene glycol), 16 acetylene dendron, generation 3

average Mn 8,000

Synonym: Bis-MPA poly(ethylene glycol), Bis[2,2-bis(hydroxymethyl)propanoic acid] PEG, Dendron functionalized PEG acetylene, generation 3, PEG-6000, PFD-G3-PEG6k-Acetylene

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Properties

Related Categories Dendrimers, Materials Science, Nanomaterials, PEG-core Dendrimers
Quality Level   100
description   acetylene surface groups
mol wt   PEG average Mn 6,000 (n~130, esterified with 16 acetylene groups)
  Mn 7500-9500 (by NMR)
  average Mn 8,000
feature   generation 3
no. Surface Groups   16
mp   43-47 °C
functional group   acetylene

Description

General description

Dendrimers and dendrons are symmetrically branched polymer structures that possess a well-defined spatial distribution of functional groups. Dendrimers are chemically modified by attaching poly ethylene glycol (PEG) molecule to increase its solubility and prolong circulation half-life.“Clickable groups”, such as primary acetylenes, are introduced to the mono dispersed dendritic structures, using “click” chemistry. These acetylene groups, attached to Bis-MPA based dendrons, allow it to form the conjugates with bioactive moieties such as carbohydrate, fluorescent dyes, disaccharides etc.

Application

The proposed uses are
• as an efficient drug delivery system.
• In vitro toxicological studies
• In vivo via radionuclide labeling and optical imaging
• Biosensors
• Dip pen nanolithography

Packaging

500 mg in glass insert

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
Flash Point(F) 
No data available
Flash Point(C) 
No data available

Documents

Certificate of Analysis (COA)

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Protocols & Articles

Articles

Biocompatible Dendritic Building Blocks for Advanced Biomedical Research

Dendrimers and dendrons are symmetrically branched polymer structures that possess a well-defined spatial distribution of functional groups. These dendritic materials have attracted considerable inte...
1Dr. Michael Malkoch and 2Dr. Andreas M. Nyström
Material Matters, 2012 v7, n3
Keywords: Applications, Asymmetric synthesis, Bacterial conjugations, Building blocks, Cancer, Catalysis, Chemical reactions, Click chemistry, Diagnostic, Diagnostic Imaging, Materials Science, Nanomaterials, Solvents, Type

Polyethylene Glycol (PEG) Selection Guide

Poly(ethylene glycol) (PEG) is a synthetic, hydrophilic, biocompatible polymer with widespread use in biomedical and other applications. PEGs are synthesized using a ring-opening polymerization of et...
Keywords: Adhesion, Bacterial conjugations, Click chemistry, Molecular biology, PEGylations, Polymerization reactions, Ring-opening polymerization

Peer-Reviewed Papers
15

References

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