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792454 Sigma-Aldrich

Palau′Chlor®

95%

Synonym: 2-Chloro-1,3-bis(methoxycarbonyl)guanidine, Baran CBMG Reagent

  • Empirical Formula (Hill Notation) C5H8ClN3O4

  • Molecular Weight 209.59

  •  MDL number MFCD28016343

  •  PubChem Substance ID 329768336

  •  NACRES NA.22

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Properties

Related Categories C-X Bond Formation (Halogen), Chemical Synthesis, Chlorination, Reproducibility: Validated Products, Synthetic Reagents,
Quality Level   100
assay   95%
mp   115-120 °C
storage temp.   2-8°C
SMILES string   O=C(NC(NC(OC)=O)=NCl)OC
InChI   1S/C5H8ClN3O4/c1-12-4(10)7-3(9-6)8-5(11)13-2/h1-2H3,(H2,7,8,9,10,11)
InChI key   PCUVYBUDIWDLNI-UHFFFAOYSA-N

Description

Application

Palau′Chlor® is an electrophilic reagent that is useful in the chlorination of aromatic and heteroaromatic substrates, as well as the alpha-chlorination of carbonyl compounds. Palau′Chlor® is an air-stable, free-flowing powder that combines reactivity and practicality, providing an excellent alternative to conventional chlorinating agents such as N-chlorosuccinimide and tert-butyl hypochlorite.

Learn More at the Professor and Product Portal of Professor Phil S. Baran.

Palau’chlor: A Practical and Reactive Chlorinating Reagent

Packaging

1 kg in poly bottle

1, 10, 100 g in poly bottle

Legal Information

Palau'Chlor is a registered trademark of Sigma-Aldrich Co. LLC

Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
Precautionary statements 
Target organs 
Respiratory system
RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Protocols & Articles

Articles

Palau’Chlor®: Easily and Selectively Functionalize Lead Compounds

Aryl chlorides are commonly used in cross-coupling reactions and can serve as key intermediates towards the synthesis of pharmaceutical drug candidates and natural products. Therefore, the addition o...
Keywords: Chlorinations, Coupling reactions, Cross couplings, PAGE, Pharmaceutical

Professor Product Portal - Baran Group

From our library of Articles, Sigma-Aldrich presents Professor Product Portal - Baran Group
Keywords: Building blocks, Fluorinations, Oxidations, Pharmaceutical

Peer-Reviewed Papers
15

References

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