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86734 Sigma-Aldrich

1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetraacetic acid

≥97.0% (CHN)

Synonym: DOTA

  • CAS Number 60239-18-1

  • Empirical Formula (Hill Notation) C16H28N4O8 · xH2O

  • Molecular Weight 404.42 (anhydrous basis)

  •  Beilstein/REAXYS Number 1186987

  •  MDL number MFCD00068657

  •  PubChem Substance ID 57653192

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Properties

Related Categories Chelation/Complexation Compounds, Chemical Synthesis, Crown Ethers, Synthetic Reagents
Quality Level   100
assay   ≥97.0% (CHN)
SMILES string   OC(=O)CN1CCN(CCN(CCN(CC1)CC(O)=O)CC(O)=O)CC(O)=O
InChI   1S/C16H28N4O8/c21-13(22)9-17-1-2-18(10-14(23)24)5-6-20(12-16(27)28)8-7-19(4-3-17)11-15(25)26/h1-12H2,(H,21,22)(H,23,24)(H,25,26)(H,27,28)
InChI key   WDLRUFUQRNWCPK-UHFFFAOYSA-N

Description

Application

1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA) is a macrocyclic complexing agent.
• It has been used for radiolabeling of carbon nanotube bioconjugates by chelating 64Cu radioisotope.
• DOTA can be activated with N-hydroxysulfosuccinimidyl for conjugation with monoclonal antibodies in clinical radioimmunotherapy.
• It can form complexes with gadolinium for application as MRI contrast agents.
• Metal complexes of DOTA-peptide conjugates can be used as therapeutic radiopharmaceuticals.

Packaging

50, 250 mg in poly bottle

Safety & Documentation

Safety Information

Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Protocols & Articles
Peer-Reviewed Papers
15

References

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