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T101 Sigma-Aldrich

Gaboxadol hydrochloride

solid, ≥98% (HPLC)

Synonym: 4,5,6,7-Tetrahydroisoxazolo[5,4-c]pyridin-3-ol hydrochloride, THIP hydrochloride

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Properties

Related Categories Agonists, Building Blocks, Cell Biology, Cell Signaling and Neuroscience, Chemical Synthesis,
Quality Level   100
assay   ≥98% (HPLC)
form   solid
color   white
solubility   ethanol: 0.91 mg/mL
  H2O: 20 mg/mL
SMILES string   Cl[H].Oc1noc2CNCCc12
InChI   1S/C6H8N2O2.ClH/c9-6-4-1-2-7-3-5(4)10-8-6;/h7H,1-3H2,(H,8,9);1H
InChI key   ZDZDSZQYRBZPNN-UHFFFAOYSA-N
Gene Information   human ... GABRA1(2554), GABRA2(2555), GABRA3(2556), GABRA4(2557), GABRA5(2558), GABRA6(2559), GABRB1(2560), GABRB2(2561), GABRB3(2562)

Description

General description

Gaboxadol, also referred to as 4,5,6,7-tetrahydroisoxazolo(5,4-c)pyridin-3-ol (THIP), is a GABA site agonist. It has great affinity to the δ subunit of extrasynaptic high-affinity GABAA receptors. Gaboxadol was first developed for the treatment of schizophrenia, epilepsy, primary insomnia and Huntington’s disease. It can easily cross the blood-brain barrier and is rapidly absorbed by the body.

Application

Gaboxadol hydrochloride has been used in cell migration and invasion assay to assess liver cancer cell migration.

Packaging

25, 100, 500 mg in glass bottle

Biochem/physiol Actions

GABAA receptor agonist.

Caution

Photosensitive

Safety & Documentation

Safety Information

Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
3
RTECS 
NY3396800

Documents

Certificate of Analysis (COA)

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Certificate of Origin (COO)

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Meet Synthia - Retrosynthesis Sofware
Protocols & Articles
Peer-Reviewed Papers
15

References

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