W387509 Sigma-Aldrich

Dimethyl sulfoxide


Synonym: DMSO

  • CAS Number 67-68-5

  • Linear Formula (CH3)2SO

  • Molecular Weight 78.13

  •  FEMA Number 3875

  •  Beilstein/REAXYS Number 506008

  •  EC Number 200-664-3

  •  MDL number MFCD00002089

  •  PubChem Substance ID 24901911

  •  Flavis number 12.175



Related Categories A - D, Alphabetical Listings, Flavors and Fragrances, Halal Certified Products, I - N,
biological source   synthetic
grade   Halal
vapor density   2.7 (vs air)
vapor pressure   0.42 mmHg ( 20 °C)
assay   ≥99%
autoignition temp.   573 °F
shelf life   Expiration date period - 5 years
expl. lim.   42 %, 63 °F
color   colorless
refractive index   n20/D 1.479 (lit.)
bp   189 °C (lit.)
  189 °C
mp   16-19 °C (lit.)
solubility   water: miscible
density   1.10 g/mL (lit.)
Agency/Method   meets purity specifications of JECFA
Documentation   see Safety & Documentation for available documents
Organoleptic   butter; sulfurous
food allergen   no known allergens
SMILES string   CS(C)=O
InChI   1S/C2H6OS/c1-4(2)3/h1-2H3


General description

Dimethyl sulfoxide (DMSO) is a hygroscopic, high polarity amphiphilic solvent with an ability to dissolve many compounds. Cytotoxic study of DMSO on the pulp tissue repair-related activity of odontoblast-like cells showed it produced minor effects. Along with phosphorus pentaoxide it participates in the oxidation of carbohydrates to afford aldosuloses and aldosiduloses. DMSO participates in the oxidation of some partially-acetylated carbohydrates followed by elimination to afford unsaturated, derivatives. Solubility of amylose and amylopectin in DMSO has been evaluated.


DMSO has been used to prepare the DMSO-phosphate buffer solution, which was used to dissolve the selective ETB (ET = endothelin) receptor antagonist in a study. It has been used for the preparation of nysatin solution.

Dimethyl sulfoxide may be used in the synthesis of the following:
• α, β−Unsaturated carbonyl sugar derivatives.
• Conversion of secondary bromides or olefins to bromohydrin.
• Synthesis of α-hydroxycarbonyls from corresponding ketones.


Supercools easily and remelts slowly at room temperature. Solidified product can be re-liquified by warming to room temperature without detriment to the product.

Other Notes

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Safety & Documentation

Safety Information

WGK Germany 
Flash Point(F) 
188.6 °F
Flash Point(C) 
87 °C
Protocols & Articles


LPL Activity Assay Protocol

The kit is sufficient for 100 assays in 200 µL total assay volume. Substrate Emulsion                                    0.125 mL Catalog Number MAK109A LPL Standard, 75.7 mM                         ...
Keywords: Sample preparations

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Flavors and Fragrances Quality and Regulatory

From a comprehensive vendor approval process, to the testing of raw material at receipt as well as when product is ready to be shipped; we prove our dedication to supply chain transparency, every day.
Keywords: Allergens, Food Safety, Solvents

Peer-Reviewed Papers


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