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850103P Avanti

17:1 Lyso PI

1-(10Z-heptadecenoyl)-2-hydroxy-sn-glycero-3-phospho-(1′-myo-inositol) (ammonium salt), powder

Synonym: PI(17:1(10Z)/0:0); 110718

  • CAS Number 1246353-39-8

  • Empirical Formula (Hill Notation) C26H52NO12P

  • Molecular Weight 601.66

  •  NACRES NA.25

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Properties

Related Categories Avanti PI, PIP & LPI, Avanti Phospholipids, Avanti Polar Lipids Products, Biochemicals and Reagents, Lipids More...
assay   >99% (LPI; may contain up to 10% of the 2-LPI isomer, TLC)
form   powder
packaging   pkg of 1 × 100 μg (with stopper and crimp cap (850103P-100ug))
  pkg of 1 × 500 μg (with stopper and crimp cap (850103P-500ug))
mfr. no.   Avanti Polar Lipids, 850103P
shipped in   dry ice
storage temp.   −20°C
SMILES string   [H][C@@](COP([O-])(O[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](O)[C@H]1O)=O)(O)COC(CCCCCCCC/C=C\CCCCCC)=O.[NH4+]

Description

General description

Lysophosphatidylinositol (LPI), a degradation product of phosphatidylinositol (PI) is a lysophospholipid subspecies, which carries inositol in its head group.

Application

17:1 Lyso PI (1-(10Z-heptadecenoyl)-2-hydroxy-sn-glycero-3-phospho-(1′-myo-inositol)) has been used as an internal standard in LC-MS of mice brain lipidomic analysis. It may be used as internal standard in for the analysis of lysophosphatidylinositols (LPIs) in mice using high-performance liquid chromatography/electrospray ionization tandem mass spectrometry (HPLC/ESI-MS) and in the quantification of lysoPI (LPI) in livers of chronic high-fat diet (HFD)-fed WT and KO mice using liquid chromatography with tandem mass spectrometry (LC-MS-MS) system.

Biochem/physiol Actions

Increased circulating levels of L-alpha-lysophosphatidylinositol (LPI) are associated with cancer and LPI is a potent ligand for the G-protein-coupled receptor GPR55.

Lysophosphatidylinositol (LPI) serve as a bioactive lysophospholipid mediator. It favors mitogenic activity in quiescent fibroblasts. LPI has the ability to block hippocampal neuronal death in conditions of forebrain ischemia.

Packaging

2 mL Amber Serum Vial with Stopper and Crimp Cap (850103P-100ug)

2 mL Amber Serum Vial with Stopper and Crimp Cap (850103P-500ug)

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
Flash Point(F) 
No data available
Flash Point(C) 
No data available

Documents

Certificate of Analysis (COA)

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Protocols & Articles

Articles

Storage & Handling of Lipids - Avanti® Polar Lipids

The following statements pertain specifically to Avanti’s lipid products for research and should not necessarily be applied to cGMP lipids intended for pharmaceutical or diagnostic applications.
Keywords: Diagnostic, Oxidations, Pharmaceutical, Solvents

Protocols

Determination of Phospholipid Oxidation by UV/VIS Spectroscopy - Avanti® Polar Lipids

The percent oxidation of a phospholipid can be determined by using Beer’s Law to calculate the peroxidized phospholipid’s concentration from its absorbance at 234 nm.
Keywords: Extinction coefficient, Oxidations

General Lipid/BSA Solubilization Protocol For Cell Delivery

Water Solutions: Solubilizing some lipids is difficult using organic solvents. Typically, lipids are suspended in methanol to aliquot, the methanol is then dried and the residue dispersed using fatty...
Keywords: Evaporation, Solvents

Peer-Reviewed Papers
15

References

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