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A-060 Supelco

Amiodarone hydrochloride solution

1.0 mg/mL in methanol (as free base), ampule of 1 mL, certified reference material, Cerilliant®

  • CAS Number 19774-82-4

  • Empirical Formula (Hill Notation) C25H30ClI2NO3

  • Molecular Weight 681.77

  •  EC Number 200-659-6

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Properties

Related Categories Additional Standards, Analytical Standards, Analytical/Chromatography, Cardiac Drug Standards, Cardiac Drugs,
grade   certified reference material
InChI Key   ITPDYQOUSLNIHG-UHFFFAOYSA-N
feature   SNAP-N-SPIKE®, SNAP-N-SHOOT®
packaging   ampule of 1 mL
mfr. no.   Cerilliant®
concentration   1.0 mg/mL in methanol (as free base)
Featured Industry   Pharmaceutical (small molecule)
format   single component solution
storage temp.   −20°C

Description

General description

Amiodarone, marketed as Pacerone®, Cordarone®, Aratac, and Atlansil, is an antiarrhythmic agent monitored by clinical labs using HPLC or LCMS to ensure patients remain within the drugs therapeutic range.

Legal Information

CERILLIANT is a registered trademark of Cerilliant Corporation

Cordarone is a registered trademark of Sanofi S.A.

Pacerone is a registered trademark of Upsher-Smith Laboratories, Inc.

Snap-N-Shoot is a registered trademark of Cerilliant Corporation

Snap-N-Spike is a registered trademark of Cerilliant Corporation

Safety & Documentation

Safety Information

Symbol 
Signal word 
Danger
Hazard statements 
Precautionary statements 
RIDADR 
UN1230 - class 3 - PG 2 - Methanol, solution
WGK Germany 
1
Flash Point(F) 
48.2 °F
Flash Point(C) 
9 °C

Documents

Certificate of Analysis

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Protocols & Articles

Articles

Cardiac Drugs

Worldwide cardiovascular disease (CVD) prevalence is increasing, with countries such as China projecting a 73% increase in their CVD rates by 20301 and England projecting a 15% increase by 2020.2 Nea...
Keywords: Anticoagulants, Antihypertensives, Cardiovascular, Chemical vapor deposition, Clinical, Diagnostic, Forensic, Ion-exchange chromatography, Metabolites

Investigating Matrix Interference in Analysis of Antiarrhythmic Cardiac Drugs in Plasma

For efficient therapeutic drug monitoring, it is important for clinicians to have access to fast and robust analytical methods for accurate assessment of drug efficacy. Industrial trends toward highl...
Keywords: Chromatography, Filtration, High performance liquid chromatography, Immunoassay, Mass spectrometry, Metabolites, Phase transitions, Precipitation, Reversed-phase chromatography, Sample preparations, Separation, Solid phase extractions, Solvents

LC/MS (TOF) Analysis of Antiarrhythmic Drugs and Metabolites in Plasma on Ascentis® Express HILIC after Sample Prep using HybridSPE®-Phospholipid

From our library of Articles, Sigma-Aldrich presents LC/MS (TOF) Analysis of Antiarrhythmic Drugs and Metabolites in Plasma on Ascentis® Express HILIC after Sample Prep using HybridSPE®-Phospholipid
Keywords: Chromatography, Clinical, High performance liquid chromatography, Mass spectrometry, Pharmaceutical, Sample preparations, Separation, Solid phase extractions, Solvents

LC/MS (TOF) Analysis of Antiarrhythmic Drugs and Metabolites on Ascentis® Express HILIC: Improvement in Analyte Response after Solid Phase Extraction (SPE) using HybridSPE®-Phospholipid

From our library of Articles, Sigma-Aldrich presents LC/MS (TOF) Analysis of Antiarrhythmic Drugs and Metabolites on Ascentis® Express HILIC: Improvement in Analyte Response after Solid Phase Extraction (SPE) using HybridSPE®-Phospholipid
Keywords: Chromatography, Clinical, High performance liquid chromatography, Mass spectrometry, Metabolites, Pharmaceutical, Precipitation, Sample preparations, Separation, Solid phase extractions, Solvents

LC/MS (TOF) Analysis of Antiarrhythmic Drugs and Metabolites on Ascentis® Express HILIC

From our library of Articles, Sigma-Aldrich presents LC/MS (TOF) Analysis of Antiarrhythmic Drugs and Metabolites on Ascentis® Express HILIC
Keywords: Chromatography, Clinical, High performance liquid chromatography, Mass spectrometry, Pharmaceutical, Separation, Solvents

LC/MS Analysis of Antiarrhythmic Drugs and Metabolites in Plasma on Ascentis® Express HILIC following Sample Prep using HybridSPE®-Phospholipid

From our library of Articles, Sigma-Aldrich presents LC/MS Analysis of Antiarrhythmic Drugs and Metabolites in Plasma on Ascentis® Express HILIC following Sample Prep using HybridSPE®-Phospholipid
Keywords: Chromatography, Clinical, High performance liquid chromatography, Liquid chromatography mass spectrometry, Mass spectrometry, Sample preparations, Solid phase extractions, Solvents

LC/MS Analysis of Antiarrhythmic Drugs and Metabolites on Ascentis® Express HILIC

From our library of Articles, Sigma-Aldrich presents LC/MS Analysis of Antiarrhythmic Drugs and Metabolites on Ascentis® Express HILIC
Keywords: Chromatography, Clinical, High performance liquid chromatography, Mass spectrometry, Reversed-phase chromatography, Separation, Solid phase extractions

LC/MS/MS Analysis of Interacting Cardiac Drugs Digoxin, Quinidine, Amiodarone and Verapamil on Titan™ C18

From our library of Articles, Sigma-Aldrich presents LC/MS/MS Analysis of Interacting Cardiac Drugs Digoxin, Quinidine, Amiodarone and Verapamil on Titan™ C18
Keywords: Antihypertensives, Chromatography, Clinical, High performance liquid chromatography, Liquid chromatography mass spectrometry, Mass spectrometry, Precipitation, Solid phase extractions

Matrix Inferference in Analysis of Cardiac Drugs in Plasma

For efficient therapeutic drug monitoring, it is important for clinicians to have access to fast and robust analytical methods to ensure accurate assessment of drug efficacy. Industrial trends toward...
Craig Aurand
Reporter US Volume 31.1
Keywords: Chromatography, Filtration, High performance liquid chromatography, Immunoassay, Liquid chromatography mass spectrometry, Mass spectrometry, Metabolites, Phase transitions, Precipitation, Reversed-phase chromatography, Sample preparations, Separation, Solid phase extractions, Solvents

Therapeutic Drug Monitoring Standards

Therapeutic drug monitoring (TDM) measures drug concentrations in blood and other biological fluids to ensure maintenance of a drug’s therapeutic range. TDM is performed routinely to guide the dosing...
Keywords: Anti-depressants, Anticonvulsants, Antifungals, Cancer, High performance liquid chromatography, Immunoassay, Ion-exchange chromatography, Liquid chromatography mass spectrometry, Mass spectrometry

Peer-Reviewed Papers
15

References

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A-083 Amiodarone-D4 hydrochloride solution, 100 μg/mL in methanol (as free base), ampule of 1 mL, certified reference material, Cerilliant®
D-055 N-Desethylamiodarone hydrochloride solution, 1.0 mg/mL in methanol (as free base), ampule of 1 mL, certified reference material, Cerilliant®
D-056 N-Desethylamiodarone-D4 hydrochloride solution, 100 μg/mL in methanol (as free base), ampule of 1 mL, certified reference material, Cerilliant®

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