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A-122 Cerilliant

Arachidonic acid

1.0 mg/mL in ethanol, certified reference material

Synonym: cis,cis,cis,cis-5,8,11,14-Eicosatetraenoic acid, Eicosa-5Z,8Z,11Z,14Z-tetraenoic acid, Immunocytophyte

  • CAS Number 506-32-1

  • Linear Formula CH3(CH2)4(CH=CHCH2)4CH2CH2CO2H

  • Molecular Weight 304.47

  •  Beilstein Registry Number 1713889

  •  MDL number MFCD00004417

  •  PubChem Substance ID 329770689

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Properties

grade   certified reference material
InChI Key   YZXBAPSDXZZRGB-DOFZRALJSA-N
feature   Snap-N-Spike®/Snap-N-Shoot®
packaging   ampule of 1 mL
concentration   1.0 mg/mL in ethanol
refractive index   n20/D 1.4872(lit.)
bp   169-171 °C/0.15 mmHg(lit.)
mp   −49 °C(lit.)
density   0.922 g/mL at 25 °C(lit.)
format   single component solution
storage temp.   −20°C

Description

Biochem/physiol Actions

Arachidonic acid (AA) is an unsaturated ω6 fatty acid constituent of the phospholipids of cell membranes. Phospholipase A2 releases AA from the membrane phospholipids in response to inflammation. AA is subsequently metabolized to prostaglandins and thromboxanes by at least two cyclooxygenase (COX) isoforms, to leukotrienes and lipoxins by lipoxygenases, and to epoxyeicosatrienoic acids via cytochrome p450-catalyzed metabolism. AA and its metabolites play important roles in a variety of biological processes, including signal transduction, smooth muscle contraction, chemotaxis, cell proliferation and differentiation, and apoptosis. AA has been demonstrated to bind to the a subunit of G protein and inhibit the activity of Ras GTPase-activating proteins (GAPs). Cellular uptake of AA is energy dependent and involves protein-facilitated transport across the plasma membrane.

Arachidonic acid stimulates adhesion of MDA-MB-435 human metastatic cancer cells to extracellular matrix molecules (collagen IV and vitronectin) .

General description

A Certified Spiking Solution® suitable for use in mass spectrometry-based fatty acid testing applications such as assessment of cardiovascular disease risk and fatty acid deficiency, and detection and quantification of arachidonic acid in nutraceuticals and dietary supplements. Arachidonic acid (cis-5,8,11,14), sometimes referred to as AA or ARA, is a polyunsaturated omega-6 fatty acid. Studies suggests that ARA as well as other fatty acids can serve as biomarkers for cardiovascular disease, and nutritional and metabolic disorders.

Legal Information

CERTIFIED SPIKING SOLUTION is a registered trademark of Cerilliant Corporation

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Safety & Documentation

Safety Information

Symbol 
Signal word 
Danger
Hazard statements 
RIDADR 
UN1170 - class 3 - PG 2 - Ethanol
WGK Germany 
1
Flash Point(F) 
57.2 °F
Flash Point(C) 
14 °C
Protocols & Articles
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