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1.52022 Supelco

Chromolith® HighResolution RP-18 endcapped 100-4.6 HPLC column

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Properties

Related Categories Analytical/Chromatography, HPLC/UHPLC More...
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Description

General description

All Chromolith® HighResolution columns are made of monolithic silica with a characteristic bimodal pore structure. Chromolith 4.6 mm columns have macropores with 1.15 µm diameter, giving a column efficiency exceeding 140,000 plates/meter. The mesopores are 15 nm (150 Å), the surface modification is octadecylsilan with full end-capping.

Analysis Note

Appearance: passes test
Pressure: 40 - 70 bar
stability testing: passes test
Performance (anthracene)
Theoretical Plates (N/m) (Anthracene): ≥ 140000
Capacity factor (Anthracene): 3.9 - 4.6
Tailing (USP): 0.90 - 1.30 %
Selectivity
separation factor (anthracene/progesterone): 1.95 - 2.35

Legal Information

Chromolith is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety & Documentation

Safety Information

Safety Information for this product is unavailable at this time.
Protocols & Articles

Articles

Chromolith® HPLC and UHPLC columns

Chromolith® HPLC and UHPLC columns are made from monolithic silica with a bimodal pore structure using sol-gel technology. There are no silica particles.
Keywords: High performance liquid chromatography, Sample preparations, Separation, Sol-gel

Esomeprazole Identification and Assay by HPLC

Esomeprazole Magnesium and Esomeprazole Magnesium Delayed-Release Capsules USP Monograph Methods
Keywords: Absorption, Atomic absorption spectroscopy, Chromatography, High performance liquid chromatography, Infrared spectroscopy, Karl Fischer titrations, Titrations

HPLC Analysis Report of Organic Acids on Chromolith® High Resolution RP-18e

From our library of Articles, Sigma-Aldrich presents HPLC Analysis Report of Organic Acids on Chromolith® High Resolution RP-18e
Keywords: High performance liquid chromatography

HPLC Analysis of Albuterol Tablets - Assay on Chromolith HighResolution RP-18 endcapped 100 x 4.6mm

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Albuterol Tablets - Assay on Chromolith HighResolution RP-18 endcapped 100 x 4.6mm
Keywords: High performance liquid chromatography, Pharmaceutical, Sample preparations

HPLC Analysis of Amlodipine & Olmesartan in tablet on Chromolith® High Resolution RP18e

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Amlodipine & Olmesartan in tablet on Chromolith® High Resolution RP18e
Keywords: Antihypertensives, Chromatography, High performance liquid chromatography

HPLC Analysis of Amlodipine Besylate in tablet on Chromolith® High Resolution RP-18e

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Amlodipine Besylate in tablet on Chromolith® High Resolution RP-18e
Keywords: High performance liquid chromatography, Pharmaceutical

HPLC Analysis of Antibacterials on Chromolith® High Resolution RP-18e

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Antibacterials on Chromolith® High Resolution RP-18e
Keywords: Cosmetics, High performance liquid chromatography

HPLC Analysis of Biphenyles on Chromolith® High Resolution RP-18e

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Biphenyles on Chromolith® High Resolution RP-18e
Keywords: High performance liquid chromatography

HPLC Analysis of Bisphenol A in Milk Powder on Chromolith® High Resolution RP-18e

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Bisphenol A in Milk Powder on Chromolith® High Resolution RP-18e
Keywords: Fluorescence detector

HPLC Analysis of Bisphenol A in Spiked Milk Powder on Chromolith® High Resolution RP-18e

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Bisphenol A in Spiked Milk Powder on Chromolith® High Resolution RP-18e
Keywords: Fluorescence detector, High performance liquid chromatography, Sample preparations

HPLC Analysis of Carbidopa on Chromolith® High Resolution RP-18e

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Carbidopa on Chromolith® High Resolution RP-18e
Keywords: High performance liquid chromatography, Pharmaceutical

HPLC Analysis of Carvedilol in Tablet on Chromolith® High Resolution RP-18e

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Carvedilol in Tablet on Chromolith® High Resolution RP-18e
Keywords: High performance liquid chromatography, Pharmaceutical, Sample preparations

HPLC Analysis of Cefixime and Ofloxacin in Tablets on Chromolith® High Resolution RP-18e

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Cefixime and Ofloxacin in Tablets on Chromolith® High Resolution RP-18e
Keywords: High performance liquid chromatography, Pharmaceutical, Sample preparations

HPLC Analysis of Cetirizine on Chromolith® High Resolution RP-18e

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Cetirizine on Chromolith® High Resolution RP-18e
Keywords: High performance liquid chromatography, Pharmaceutical

HPLC Analysis of Chloropheniramine Maleate & Related Impurities on Chromolith® High Resolution RP18e

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Chloropheniramine Maleate & Related Impurities on Chromolith® High Resolution RP18e
Keywords: Chromatography, High performance liquid chromatography, Pharmaceutical

HPLC Analysis of Ciprofloxacin in Plasma on Chromolith® High Resolution RP-18e

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Ciprofloxacin in Plasma on Chromolith® High Resolution RP-18e
Keywords: High performance liquid chromatography, Pharmaceutical

HPLC Analysis of Contents of Energy Drinks on Chromolith® High Resolution RP-18e

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Contents of Energy Drinks on Chromolith® High Resolution RP-18e
Keywords: High performance liquid chromatography, Sample preparations

HPLC Analysis of Diclofenac and Metabolits on Chromolith® High Resolution RP-18e

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Diclofenac and Metabolits on Chromolith® High Resolution RP-18e
Keywords: High performance liquid chromatography, Pharmaceutical, Sample preparations

HPLC Analysis of Esomeprazole Magnesium on Chromolith® HighResolution RP-18 endcapped 100 x 4.6mm

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Esomeprazole Magnesium on Chromolith® HighResolution RP-18 endcapped 100 x 4.6mm
Keywords: High performance liquid chromatography, Pharmaceutical

HPLC Analysis of Ethacrynic Acid on Chromolith® HighResolution RP-18endcapped, 100 x 4.6 mm

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Ethacrynic Acid on Chromolith® HighResolution RP-18endcapped, 100 x 4.6 mm
Keywords: High performance liquid chromatography, Pharmaceutical

HPLC Analysis of Finasteride Tablets on Chromolith® HighResolution RP-18 endcapped 100 x 4.6mm

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Finasteride Tablets on Chromolith® HighResolution RP-18 endcapped 100 x 4.6mm
Keywords: High performance liquid chromatography, Pharmaceutical, Sample preparations

HPLC Analysis of Flavonoids in Red Wine on Chromolith High Resolution RP-18e (analyte set 1)

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Flavonoids in Red Wine on Chromolith High Resolution RP-18e (analyte set 1)
Keywords: High performance liquid chromatography

HPLC Analysis of Flavonoids in Red Wine on Chromolith High Resolution RP-18e (analyte set 2)

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Flavonoids in Red Wine on Chromolith High Resolution RP-18e (analyte set 2)
Keywords: High performance liquid chromatography

HPLC Analysis of Folic Acid Syrup on Chromolith High Resolution RP-18

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Folic Acid Syrup on Chromolith High Resolution RP-18
Keywords: High performance liquid chromatography, Sample preparations

HPLC Analysis of Ganciclovir Injection Solution on Chromolith® HighResolution RP-18 endcapped 100 x 4.6mm

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Ganciclovir Injection Solution on Chromolith® HighResolution RP-18 endcapped 100 x 4.6mm
Keywords: High performance liquid chromatography, Pharmaceutical, Sample preparations

HPLC Analysis of Hinokitiol on Chromolith® High Resolution RP-18e

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Hinokitiol on Chromolith® High Resolution RP-18e
Keywords: High performance liquid chromatography, Vitamins

HPLC Analysis of Hormone on Chromolith® High Resolution RP-18e

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Hormone on Chromolith® High Resolution RP-18e
Keywords: High performance liquid chromatography

HPLC Analysis of Huaijiao Wan Tablets at 260 nm and 280 nm on Chromolith® HighResolution RP-18 endcapped

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Huaijiao Wan Tablets at 260 nm and 280 nm on Chromolith® HighResolution RP-18 endcapped
Keywords: High performance liquid chromatography, Sample preparations, Vitamins

HPLC Analysis of Hydroxymethylfurfural in Honey on Chromolith® High Resolution RP-18e

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Hydroxymethylfurfural in Honey on Chromolith® High Resolution RP-18e
Keywords: High performance liquid chromatography, Sample preparations

HPLC Analysis of Hydroxymethylfurfural on Chromolith® High Resolution RP18e

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Hydroxymethylfurfural on Chromolith® High Resolution RP18e
Keywords: Chromatography, High performance liquid chromatography

HPLC Analysis of Ibuprofen & Codeine Phosphate Tablet on Chromolith® High Resolution RP18e

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Ibuprofen & Codeine Phosphate Tablet on Chromolith® High Resolution RP18e
Keywords: Chromatography, High performance liquid chromatography, Pharmaceutical, Sample preparations

HPLC Analysis of Ilvico on Chromolith® High Resolution RP-18e

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Ilvico on Chromolith® High Resolution RP-18e
Keywords: High performance liquid chromatography, Pharmaceutical

HPLC Analysis of Itraconazole and Impurties on Chromolith® High Resolution RP-18e

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Itraconazole and Impurties on Chromolith® High Resolution RP-18e
Keywords: High performance liquid chromatography, Pharmaceutical, Sample preparations

HPLC Analysis of Ivermectin Injection as per USP/BP on Chromolith® High Resolution RP-18e

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Ivermectin Injection as per USP/BP on Chromolith® High Resolution RP-18e
Keywords: High performance liquid chromatography, Pharmaceutical

HPLC Analysis of Levetiracetam on Chromolith® High Resolution RP-18e

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Levetiracetam on Chromolith® High Resolution RP-18e
Keywords: High performance liquid chromatography, Pharmaceutical

HPLC Analysis of Loratadine Tablets on Chromolith® HighResolution RP-18 endcapped

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Loratadine Tablets on Chromolith® HighResolution RP-18 endcapped
Keywords: High performance liquid chromatography, Pharmaceutical, Sample preparations

HPLC Analysis of Loratadine on Chromolith® HighResolution RP-18 endcapped

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Loratadine on Chromolith® HighResolution RP-18 endcapped
Keywords: High performance liquid chromatography, Pharmaceutical

HPLC Analysis of Lysozyme in Cheese on Chromolith® High Resolution RP-18e

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Lysozyme in Cheese on Chromolith® High Resolution RP-18e
Keywords: High performance liquid chromatography, Sample preparations

HPLC Analysis of Melamine in Infant Forumula on Chromolith® High Resolution RP-18e

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Melamine in Infant Forumula on Chromolith® High Resolution RP-18e
Keywords: Centrifugation, High performance liquid chromatography

HPLC Analysis of Metformin & Pioglitazone on Chromolith® High Resolution RP18e

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Metformin & Pioglitazone on Chromolith® High Resolution RP18e
Keywords: Chromatography, High performance liquid chromatography, Pharmaceutical

HPLC Analysis of Nateglinide Tablets on Chromolith HighResolution RP-18 endcapped

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Nateglinide Tablets on Chromolith HighResolution RP-18 endcapped
Keywords: High performance liquid chromatography, Pharmaceutical, Sample preparations

HPLC Analysis of Organic Acids in Beverage on Chromolith® High Resolution RP-18e

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Organic Acids in Beverage on Chromolith® High Resolution RP-18e
Keywords: High performance liquid chromatography

HPLC Analysis of Organic Acids in Beverages on Chromolith® HighResolution RP-18 endcapped

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Organic Acids in Beverages on Chromolith® HighResolution RP-18 endcapped
Keywords: Chromatography, High performance liquid chromatography, Sample preparations

HPLC Analysis of Organic Acids on Chromolith® High Resolution RP-18e

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Organic Acids on Chromolith® High Resolution RP-18e
Keywords: High performance liquid chromatography

HPLC Analysis of Ranitidine on Chromolith® High Resolution RP-18e

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Ranitidine on Chromolith® High Resolution RP-18e
Keywords: High performance liquid chromatography, Pharmaceutical

HPLC Analysis of Sildenafil Citrate on Chromolith® HighResolution RP-18 endcapped 100 x 4.6mm

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Sildenafil Citrate on Chromolith® HighResolution RP-18 endcapped 100 x 4.6mm
Keywords: High performance liquid chromatography, Pharmaceutical

HPLC Analysis of Simvastatine USP on Chromolith High Resolution RP-18e (analyte set 1)

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Simvastatine USP on Chromolith High Resolution RP-18e (analyte set 1)
Keywords: High performance liquid chromatography, Pharmaceutical, Sample preparations

HPLC Analysis of Spironolactone on Chromolith® HighResolution RP-18 endcapped 100 x 4.6 mm

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Spironolactone on Chromolith® HighResolution RP-18 endcapped 100 x 4.6 mm
Keywords: High performance liquid chromatography

HPLC Analysis of Sulfonamide on Chromolith® High Resolution RP-18e

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Sulfonamide on Chromolith® High Resolution RP-18e
Keywords: High performance liquid chromatography

HPLC Analysis of Sulfonamides in Honey on Chromolith® High Resolution RP-18e

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Sulfonamides in Honey on Chromolith® High Resolution RP-18e
Keywords: High performance liquid chromatography, Sample preparations

HPLC Analysis of Sulfonamides on Chromolith® High Resolution RP-18e

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Sulfonamides on Chromolith® High Resolution RP-18e
Keywords: High performance liquid chromatography, Pharmaceutical

HPLC Analysis of Tolvaptan on Chromolith® High Resolution RP-18e

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Tolvaptan on Chromolith® High Resolution RP-18e
Keywords: High performance liquid chromatography, Pharmaceutical

HPLC Analysis of Travoprost on Chromolith® High Resolution RP-18e

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Travoprost on Chromolith® High Resolution RP-18e
Keywords: High performance liquid chromatography, Pharmaceutical

HPLC Analysis of Vitamin E on Chromolith® High Resolution RP-18e

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Vitamin E on Chromolith® High Resolution RP-18e
Keywords: High performance liquid chromatography

HPLC Analysis of Xiaoyao Wan Tablets on Chromolith® HighResolution RP-18 endcapped

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Xiaoyao Wan Tablets on Chromolith® HighResolution RP-18 endcapped
Keywords: High performance liquid chromatography, Sample preparations, Vitamins

HPLC Analysis of Xiaoyao Wan on Chromolith® HighResolution RP-18 endcapped

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Xiaoyao Wan on Chromolith® HighResolution RP-18 endcapped
Keywords: High performance liquid chromatography, Vitamins

Monolithic Silica with Bimodal Pore Structure

Thanks to their patented monolithic silica technology, Chromolith® HPLC columns allow you to race through separations with maximum robustness and selectivity—at minimal back pressure.
Keywords: Filtration, High performance liquid chromatography, Precipitation, Sample preparations, Separation, Sol-gel, Solid phase extractions

Praziquantel Determination in Aquarium Water by Direct Injection of Samples Using a Monolithic Silica Column

Praziquantel (PZQ) is used in the aquarium industry to treat monogenea and other parasites. This is often done through a bath immersion treatment, where medications are dissolved in aquarium water ra...
Bruce Herzig and Kailen Gilde
Keywords: Chromatography, Eliminations, Filtration, High performance liquid chromatography, Reductions, Sample preparations, Separation, Solid phase extractions, Solvents

UHPLC (Isocratic) Analysis of 14 Cannabinoids on Chromolith® HR RP-18e

From our library of Articles, Sigma-Aldrich presents UHPLC (Isocratic) Analysis of 14 Cannabinoids on Chromolith® HR RP-18e
Keywords: Clinical, Diseases, Forensic, Gas chromatography, High performance liquid chromatography, Mass spectrometry, Pharmaceutical, Separation

USP Dissolution Testing Method (HPLC) for Esomeprazole Magnesium Delayed Release Capsules

Esomeprazole is a proton pump inhibitor and reduces acid secretion through inhibition of the H+ / K+ ATPase in gastric parietal cells. By inhibiting the functioning of this transporter, the drug prev...
Keywords: Chromatography, High performance liquid chromatography

USP Dissolution Testing Method (HPLC) for Folic Acid Tablets using a Monolith Column and UV detection

Folic acid or folate is classified as a B vitamin (B9). Folic acid is synthetically produced, and used in fortified foods and supplements. Folate is converted by humans to dihydrofolate (dihydrofolic...
Keywords: Chromatography, High performance liquid chromatography, Sample preparations, Vitamins

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Calculates conditions for transfer of an isocratic or gradient method from one HPLC column to another. Allows method scaling from microbore through preparative column range. Calculates time and solve...
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