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01885 Sigma-Aldrich

Docetaxel

purum, ≥97.0% (HPLC)

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Properties

Related Categories Antibiotics, Apoptosis and Cell Cycle, Cell Biology, Cell Signaling and Neuroscience, Other Apoptosis Related Reagents More...
InChI Key   ZDZOTLJHXYCWBA-VCVYQWHSSA-N
grade   purum
assay   ≥97.0% (HPLC)
impurities   ~6% water
mp   186-192 °C (dec.)

Description

Biochem/physiol Actions

Docetaxel is a taxane anti-cancer agent related to paclitaxel. It binds to and stabilizes the β−tubulin subunit of microtubules, preventing depolymerization of the mitotic spindle thus leading to cell cycle arrest and apoptosis.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Application

Docetaxel can be used to study antibiotics, cell biology, cell signaling, neuroscience and apoptosis and the cell cycle. Docetaxel has been used to study the prevention of chemotherapy-induced alopecia, as well as the treatment of non-small-cell lung cancer in patients contraindicated for standard chemotherapy. Docetaxel has also been used to study the role of hypoxia-inducible factor-1α and -2α in androgen insensitive prostate cancer cells.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3
RTECS 
DA4172750

Documents

Certificate of Analysis

Frequently Asked Questions

Which document(s) contains shelf-life or expiration date information for a given product?
If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.
How do I get lot-specific information or a Certificate of Analysis?
The lot specific COA document can be found by entering the lot number above under the "Documents" section.
What is the solubility of Docetaxel, Product O1885?
This product is practically insoluble in water and soluble in ethanol, methanol, and chloroform.The solubility in TWEEN 80 is >45 mg/mL.
What is the stability ofDocetaxel, Product O1885, in solution?
When 2 mL of a 45 mg/mL solution of this product in TWEEN 80 is mixed with 6 mL of a 15.25:84.75 (v/v) solution of absolute ethanol and water, the resulting solution should be physically stable. No precipitation should be observed for at least 12 hours of storage of the resulting solution at room temperature.
IsDocetaxel, Product O1885, suitable for drug use?
No. This product is not USP grade and is therefore unsuitable for drug use. It is sold for Research & Development use only.
How do I reconstitute Docetaxel, Product O1885, for use in cell culture?
Docetaxel is soluble in ethanol, and ethanol can be tolerated as long as the dose of added ethanol is low enough.DMSO would also work as a solvent; the authors of one paper (see link below) prepared a 10 mM stock solution and used it within 7 days (final DMSO concentration was no higher than 0.2%).
What are the storage conditions for Docetaxel, Product O1885?
The product should be stored at room temperature (15°C to 25°C) and protected from light. Refrigerating and freezing does not adversely affect the product. If refrigerated, vials should be allowed to warm to room temperature before opening them.
How do I find price and availability?
There are several ways to find pricing and availability for our products.Once you log onto our website, you will find the price and availability displayed on the product detail page.You can contact any of our Customer Sales and Service offices to receive a quote. USA customers: 1-800-325-3010 orview local office numbers.
What is the Department of Transportation shipping information for this product?
Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.
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Milli-Q® Water Purification Solutions
Protocols & Articles
Peer-Reviewed Papers
15

References

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