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02487 Supelco

Chloroform

analytical standard

Synonym: Methylidyne trichloride, Trichloromethane

  • CAS Number 67-66-3

  • Empirical Formula (Hill Notation) CHCl3

  • Molecular Weight 119.38

  •  Beilstein/REAXYS Number 1731042

  •  EC Number 200-663-8

  •  MDL number MFCD00000826

  •  PubChem Substance ID 329747448

  •  NACRES NA.24

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Properties

Related Categories A-C, Additional Standards, Alpha Sort, Analytical Standards, Analytical/Chromatography,
Quality Level   100
grade   analytical standard
vapor density   4.1 (vs air)
vapor pressure   160 mmHg ( 20 °C)
assay   ≥99.9% (GC)
shelf life   limited shelf life, expiry date on the label
contains   ~0.003% amylene as stabilizer
refractive index   n20/D 1.445 (lit.)
  n20/D 1.446
bp   60.5-61.5 °C (lit.)
mp   −63 °C (lit.)
density   1.492 g/mL at 25 °C (lit.)
Featured Industry   Agriculture
Cleaning Products
Cosmetics
Environmental
Food and Beverages
Personal Care
SMILES string   ClC(Cl)Cl
InChI   1S/CHCl3/c2-1(3)4/h1H
InChI key   HEDRZPFGACZZDS-UHFFFAOYSA-N

Description

General description

Chloroform is a colorless, volatile, liquid derivative of trichloromethane with an ether-like odor. It is a commonly used laboratory solvent. Presently, it is used in the industry as a solvent and in the production of the refrigerant freon. It is majorly used in production of chlorodifluoromethane, which is a refrigerant and fluoropolymer feedstock. It degrades in air to produce phosgene, dichloromethane, formyl chloride, CO, CO2 and hydrogen chloride. It can be orally consumed or inhaled, as it can be quickly absorbed, metabolized and eliminated by mammals.

Safety & Documentation

Safety Information

Symbol 
Signal word 
Danger
Target organs 
Central nervous system
RIDADR 
UN 1888 6.1 / PGIII
WGK Germany 
WGK 3
RTECS 
FS9100000
Flash Point(F) 
does not flash
Flash Point(C) 
does not flash

Documents

Certificate of Analysis (COA)

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Protocols & Articles

Articles

GC Analysis of Class 2 Residual Solvents on Equity®-1 after SPME using 85 μm Polyacrylate Fiber

From our library of Articles, Sigma-Aldrich presents GC Analysis of Class 2 Residual Solvents on Equity®-1 after SPME using 85 μm Polyacrylate Fiber
Keywords: Chromatography, Flame ionization detector, Gas chromatography, Pharmaceutical, Size-exclusion chromatography, Solid phase microextractions

GC Analysis of Class 2 Residual Solvents on OVI-G43

From our library of Articles, Sigma-Aldrich presents GC Analysis of Class 2 Residual Solvents on OVI-G43
Keywords: Chromatography, Flame ionization detector, Gas chromatography, Pharmaceutical, Size-exclusion chromatography

GC Analysis of Class 2 Residual Solvents on VOCOL® after SPME using 85 μm Polyacrylate Fiber

From our library of Articles, Sigma-Aldrich presents GC Analysis of Class 2 Residual Solvents on VOCOL® after SPME using 85 μm Polyacrylate Fiber
Keywords: Chromatography, Flame ionization detector, Gas chromatography, Pharmaceutical, Size-exclusion chromatography, Solid phase microextractions

GC Analysis of Industrial Solvents on Equity®-1701

From our library of Articles, Sigma-Aldrich presents GC Analysis of Industrial Solvents on Equity®-1701
Keywords: Chromatography, Flame ionization detector, Gas chromatography

GC Analysis of Industrial Solvents on Equity®-1

From our library of Articles, Sigma-Aldrich presents GC Analysis of Industrial Solvents on Equity®-1
Keywords: Chromatography, Flame ionization detector, Gas chromatography, Purification, Size-exclusion chromatography

GC Analysis of Industrial Solvents on SUPELCOWAX 10

From our library of Articles, Sigma-Aldrich presents GC Analysis of Industrial Solvents on SUPELCOWAX 10
Keywords: Chromatography, Flame ionization detector, Gas chromatography, Purification

GC Analysis of Residual Solvents on SPB®-624 after SPME using 100 μm PDMS Fiber

From our library of Articles, Sigma-Aldrich presents GC Analysis of Residual Solvents on SPB®-624 after SPME using 100 μm PDMS Fiber
Keywords: Chromatography, Flame ionization detector, Gas chromatography, Pharmaceutical, Purification, Sample preparations, Solid phase microextractions

GC Analysis of Volatiles in Water on SPB®-1 after SPME using 100 μm PDMS Fiber

From our library of Articles, Sigma-Aldrich presents GC Analysis of Volatiles in Water on SPB®-1 after SPME using 100 μm PDMS Fiber
Keywords: Chromatography, Flame ionization detector, Gas chromatography, Purification, Solid phase microextractions

GC Analysis of Volatiles on SPB®-624, Direct Injection

From our library of Articles, Sigma-Aldrich presents GC Analysis of Volatiles on SPB®-624, Direct Injection
Keywords: Chromatography, Gas chromatography, Purification, Size-exclusion chromatography

GC Analysis of Volatiles on VOCOL® after SPME using 75 μm Carboxen/PDMS Fiber

From our library of Articles, Sigma-Aldrich presents GC Analysis of Volatiles on VOCOL® after SPME using 75 μm Carboxen/PDMS Fiber
Keywords: Chromatography, Gas chromatography, Mass spectrometry, Purification, Size-exclusion chromatography, Solid phase microextractions

GC Analysis of a 12-Component Chlorinated Solvents Mix on SLB®-IL60, Comparison to a Polyethylene Glycol (PEG) Column

From our library of Articles, Sigma-Aldrich presents GC Analysis of a 12-Component Chlorinated Solvents Mix on SLB®-IL60, Comparison to a Polyethylene Glycol (PEG) Column
Keywords: Chromatography, Flame ionization detector, Gas chromatography

GC Analysis of a 56-Component Industrial Solvents Mix on SLB®-IL60, Comparison to a Polyethylene Glycol (PEG) Column

From our library of Articles, Sigma-Aldrich presents GC Analysis of a 56-Component Industrial Solvents Mix on SLB®-IL60, Comparison to a Polyethylene Glycol (PEG) Column
Keywords: Chromatography, Flame ionization detector, Gas chromatography

TLC Analyis of Thiouracils on HPTLC Silica Gel 60 F 254 with Concentrating Zone

From our library of Articles, Sigma-Aldrich presents TLC Analyis of Thiouracils on HPTLC Silica Gel 60 F 254 with Concentrating Zone
Keywords: Thin layer chromatography

TLC Analysis of 4-Hydroxybenzoic Acid and 4-Hydroxybenzoic Acid Esters on HPTLC Silica Gel 60 RP-18 F254s: Effect of Eluent Stabilizer on Resolution

From our library of Articles, Sigma-Aldrich presents TLC Analysis of 4-Hydroxybenzoic Acid and 4-Hydroxybenzoic Acid Esters on HPTLC Silica Gel 60 RP-18 F254s: Effect of Eluent Stabilizer on Resolution
Keywords: Chromatography, Thin layer chromatography

TLC Analysis of Biphenylols on HPTLC Silica Gel 60 F 254 with Concentrating Zone (analyte set 2)

From our library of Articles, Sigma-Aldrich presents TLC Analysis of Biphenylols on HPTLC Silica Gel 60 F 254 with Concentrating Zone (analyte set 2)
Keywords: Thin layer chromatography

TLC Analysis of Derivatives of Urea on HPTLC NH2 F254s

From our library of Articles, Sigma-Aldrich presents TLC Analysis of Derivatives of Urea on HPTLC NH2 F254s
Keywords: Thin layer chromatography

TLC Analysis of Ingredients in Dermatological Agents on HPTLC Silica Gel 60 RP-18 WF254s

From our library of Articles, Sigma-Aldrich presents TLC Analysis of Ingredients in Dermatological Agents on HPTLC Silica Gel 60 RP-18 WF254s
Keywords: Pharmaceutical, Thin layer chromatography

TLC Analysis of Mycotoxins on HPTLC Silica 60F 254s

From our library of Articles, Sigma-Aldrich presents TLC Analysis of Mycotoxins on HPTLC Silica 60F 254s
Keywords: Agriculture, Thin layer chromatography

TLC Analysis of Polyvalent Phenols on HPTLC NH2 F254s (analyte set 2)

From our library of Articles, Sigma-Aldrich presents TLC Analysis of Polyvalent Phenols on HPTLC NH2 F254s (analyte set 2)
Keywords: Thin layer chromatography

TLC Analysis of Pyrimidine Derivatives on HPTLC NH2 F254s (analyte set 2)

From our library of Articles, Sigma-Aldrich presents TLC Analysis of Pyrimidine Derivatives on HPTLC NH2 F254s (analyte set 2)
Keywords: Thin layer chromatography

TLC Analysis of Salicylic Acid on HPTLC Silica 60F 254s

From our library of Articles, Sigma-Aldrich presents TLC Analysis of Salicylic Acid on HPTLC Silica 60F 254s
Keywords: Thin layer chromatography

TLC Analysis of Skin Cream Ingredients on HPTLC Silica gel 60 RP-18 WF254s

From our library of Articles, Sigma-Aldrich presents TLC Analysis of Skin Cream Ingredients on HPTLC Silica gel 60 RP-18 WF254s
Keywords: Chromatography, Cosmetics, Thin layer chromatography

TLC Analysis of Some Chlorophenols on HPTLC Silica Gel 60 F 254

From our library of Articles, Sigma-Aldrich presents TLC Analysis of Some Chlorophenols on HPTLC Silica Gel 60 F 254
Keywords: Thin layer chromatography

TLC Analysis of Some Pesticides on HPTLC DIOL F254s

From our library of Articles, Sigma-Aldrich presents TLC Analysis of Some Pesticides on HPTLC DIOL F254s
Keywords: Environmental, Thin layer chromatography

TLC Analysis of Steroids on HPTLC Silica Gel 60 F 254

From our library of Articles, Sigma-Aldrich presents TLC Analysis of Steroids on HPTLC Silica Gel 60 F 254
Keywords: Clinical, Thin layer chromatography

TLC Analysis of Triazines on HPTLC NH2 F254s

From our library of Articles, Sigma-Aldrich presents TLC Analysis of Triazines on HPTLC NH2 F254s
Keywords: Thin layer chromatography

TLC Analysis of Water Soluble Vitamins on HPTLC Silica Gel 60 F 254 with Concentrating Zone

From our library of Articles, Sigma-Aldrich presents TLC Analysis of Water Soluble Vitamins on HPTLC Silica Gel 60 F 254 with Concentrating Zone
Keywords: Thin layer chromatography, Vitamins

US EPA Method 502.2: GC Analysis of Volatiles on VOCOL® (105 m x 0.53 mm I.D.) after Purge & Trap using "K" Trap, ELCD Signal

From our library of Articles, Sigma-Aldrich presents US EPA Method 502.2: GC Analysis of Volatiles on VOCOL® (105 m x 0.53 mm I.D.) after Purge & Trap using "K" Trap, ELCD Signal
Keywords: Chromatography, Gas chromatography, Hall electrolytic conductivity detector, Photo-ionization detector, Purge and trap, Sample preparations

US EPA Method 502.2: GC Analysis of Volatiles on VOCOL® (105 m x 0.53 mm I.D.) after Purge & Trap using "K" Trap, PID Signal

From our library of Articles, Sigma-Aldrich presents US EPA Method 502.2: GC Analysis of Volatiles on VOCOL® (105 m x 0.53 mm I.D.) after Purge & Trap using "K" Trap, PID Signal
Keywords: Chromatography, Gas chromatography, Hall electrolytic conductivity detector, Photo-ionization detector, Purification

US EPA Method 524.2: GC Analysis of Volatiles on VOCOL® (105 m x 0.53 mm I.D.) after Purge & Trap using "K" Trap

From our library of Articles, Sigma-Aldrich presents US EPA Method 524.2: GC Analysis of Volatiles on VOCOL® (105 m x 0.53 mm I.D.) after Purge & Trap using "K" Trap
Keywords: Chromatography, Gas chromatography, Purification, Size-exclusion chromatography

US EPA Method 624: GC Analysis of Volatiles on SPB®-624 after Purge & Trap using "K" Trap, Fast GC Analysis

From our library of Articles, Sigma-Aldrich presents US EPA Method 624: GC Analysis of Volatiles on SPB®-624 after Purge & Trap using "K" Trap, Fast GC Analysis
Keywords: Chromatography, Environmental, Gas chromatography, Purification, Solid phase microextractions

US EPA Method 624: GC Analysis of Volatiles on SPB®-624 after Purge & Trap using "K" Trap

From our library of Articles, Sigma-Aldrich presents US EPA Method 624: GC Analysis of Volatiles on SPB®-624 after Purge & Trap using "K" Trap
Keywords: Chromatography, Environmental, Gas chromatography, Purification, Solid phase microextractions

US EPA Method 624: GC Analysis of Volatiles on VOCOL® (60 m x 0.53 mm I.D.) after Purge & Trap using "K" Trap

From our library of Articles, Sigma-Aldrich presents US EPA Method 624: GC Analysis of Volatiles on VOCOL® (60 m x 0.53 mm I.D.) after Purge & Trap using "K" Trap
Keywords: Chromatography, Gas chromatography, Purification, Size-exclusion chromatography

US EPA Method 8260: GC Analysis of Volatiles on SPB®-624 after Purge & Trap using "K" Trap, Fast GC Analysis

From our library of Articles, Sigma-Aldrich presents US EPA Method 8260: GC Analysis of Volatiles on SPB®-624 after Purge & Trap using "K" Trap, Fast GC Analysis
Keywords: Chromatography, Gas chromatography, Gas chromatography mass spectrometry, Mass spectrometry, Purge and trap, Purification, Solid phase microextractions

US EPA Method 8260: GC Analysis of Volatiles on SPB®-624 after Purge & Trap using "K" Trap

From our library of Articles, Sigma-Aldrich presents US EPA Method 8260: GC Analysis of Volatiles on SPB®-624 after Purge & Trap using "K" Trap
Keywords: Chromatography, Environmental, Gas chromatography, Purification, Solid phase microextractions

US EPA Method 8260: GC Analysis of Volatiles on VOCOL® after Purge & Trap using "K" Trap, Fast GC Analysis

From our library of Articles, Sigma-Aldrich presents US EPA Method 8260: GC Analysis of Volatiles on VOCOL® after Purge & Trap using "K" Trap, Fast GC Analysis
Keywords: Chromatography, Gas chromatography, Purification, Solid phase microextractions

US EPA Method 8260: GC Analysis of Volatiles on VOCOL® after Purge & Trap using "K" Trap

From our library of Articles, Sigma-Aldrich presents US EPA Method 8260: GC Analysis of Volatiles on VOCOL® after Purge & Trap using "K" Trap
Keywords: Chromatography, Gas chromatography, Purification, Solid phase microextractions

US EPA Method OLM04.2 VOA: GC Analysis of Volatiles on SPB®-624 after Purge & Trap using "K" Trap, Fast GC Analysis

From our library of Articles, Sigma-Aldrich presents US EPA Method OLM04.2 VOA: GC Analysis of Volatiles on SPB®-624 after Purge & Trap using "K" Trap, Fast GC Analysis
Keywords: Chromatography, Environmental, Gas chromatography, Purification, Solid phase microextractions

US EPA Method OLM04.2 VOA: GC Analysis of Volatiles on VOCOL® after Purge & Trap using "K" Trap, Fast GC Analysis

From our library of Articles, Sigma-Aldrich presents US EPA Method OLM04.2 VOA: GC Analysis of Volatiles on VOCOL® after Purge & Trap using "K" Trap, Fast GC Analysis
Keywords: Chromatography, Environmental, Gas chromatography, Purification, Solid phase microextractions

US EPA Method TO-17: GC Analysis of Volatiles on Equity®-1 after Collection/Desorption using Carbotrap 300 Tube

From our library of Articles, Sigma-Aldrich presents US EPA Method TO-17: GC Analysis of Volatiles on Equity®-1 after Collection/Desorption using Carbotrap 300 Tube
Keywords: Chromatography, Gas chromatography

US EPA Method TO-17: GC Analysis of Volatiles on VOCOL® after Collection/Desorption using Air Toxics Tube

From our library of Articles, Sigma-Aldrich presents US EPA Method TO-17: GC Analysis of Volatiles on VOCOL® after Collection/Desorption using Air Toxics Tube
Keywords: Air Monitoring, Chromatography, Flame ionization detector, Gas chromatography, Purification

Peer-Reviewed Papers
15

References

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