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04635 Sigma-Aldrich

Metformin hydrochloride

pharmaceutical secondary standard; traceable to USP and PhEur

Synonym: 1,1-Dimethylbiguanide hydrochloride, Metformin

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Properties

grade   certified reference material
  pharmaceutical secondary standard
InChI Key   OETHQSJEHLVLGH-UHFFFAOYSA-N
mp   223-226 °C(lit.)
pharmacopeia traceability   traceable to PhEur M0605000
  traceable to USP 1396309
storage temp.   2-8°C

Description

Biochem/physiol Actions

Metformin is an antidiabetic agent that reduces blood glucose levels and improves insulin sensitivity. Its metabolic effects, including the inhibition of hepatic gluconeogenesis, are mediated at least in part by activation of the LKB1-AMPK (AMP-activated protein kinase) pathway. Activation of this pathway also appears to be involved in the antiproliferative and proapoptotic actions of metformin in cancer cell lines.

Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
Precautionary statements 
RIDADR 
NONH for all modes of transport
WGK Germany 
3
RTECS 
DU1800000
Protocols & Articles
Peer-Reviewed Papers
15

References

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