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22030 Sigma-Aldrich

L-Carnosine

≥99.0% (NT)

Synonym: β-Alanyl-L-histidine

  • CAS Number 305-84-0

  • Empirical Formula (Hill Notation) C9H14N4O3

  • Molecular Weight 226.23

  •  Beilstein Registry Number 87671

  •  EC Number 206-169-9

  •  MDL number MFCD00005207

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Properties

InChI Key   CQOVPNPJLQNMDC-ZETCQYMHSA-N
assay   ≥99.0% (NT)
optical activity   [α]20/D +21±1°, c = 1.5% in H2O
mp   253 °C (dec.) (lit.)
  258-260 °C (dec.)
storage temp.   2-8°C

Description

Amino Acid Sequence

Ala-His

Other Notes

Substrate for the assay of carnosinase

Biochem/physiol Actions

L-Carosine is a dipeptide found at millimolar concentration in brain, muscle and the lens of the eye. In model systems it is a potent antioxidant that scavenges oxygen free radicals and transition metal ions. It blocks protein-protein and protein-DNA cross-links induced by hypochlorite anions and toxic aldehydes such as acetaldehyde, formaldehyde, and malondialdehyde, the primary product of lipid peroxidation. It also inhibits nonenzymatic protein glycation induced by aldose and ketose reducing sugars and inhibits the formation of toxic advanced glycation end products (AGE). These activities make it of interest in studies of aging, atherosclerosis, Alzheimer′s disease, and the secondary effects of diabetes.

Dipeptide with potent antioxidant and antiglycation activity; blocks nonenzymatic glycosylation and protein cross-linking induced by reactive aldehydes.

Safety & Documentation

Safety Information

WGK Germany 
2

Documents

Certificate of Analysis

Protocols & Articles
Peer-Reviewed Papers
15

References

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C9625 L-Carnosine, ~99%, crystalline

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