• USA Home
  • 328634 - 1-Methyl-2-pyrrolidinone

328634 Sigma-Aldrich


anhydrous, 99.5%

Synonym: 1-Methyl-2-pyrrolidone, N-Methyl-2-pyrrolidone, NMP

  • CAS Number 872-50-4

  • Empirical Formula (Hill Notation) C5H9NO

  • Molecular Weight 99.13

  •  Beilstein/REAXYS Number 106420

  •  EC Number 212-828-1

  •  MDL number MFCD00003193

  •  PubChem Substance ID 57648684

  •  NACRES NA.21



Related Categories Anhydrous, Anhydrous Solvents, Returnable Containers, Solvent Bottles, Solvent Packaging Options,
Quality Level   200
grade   anhydrous
vapor density   3.4 (vs air)
vapor pressure   0.29 mmHg ( 20 °C)
  0.99 mmHg ( 40 °C)
assay   99.5%
form   liquid
autoignition temp.   518 °F
expl. lim.   9.5 %
impurities   <0.005% water
refractive index   n20/D 1.47 (lit.)
pH   7.7-10.0 (20 °C, 100 g/L)
bp   202 °C (lit.)
  81-82 °C/10 mmHg (lit.)
mp   −24 °C (lit.)
density   1.028 g/mL at 25 °C (lit.)
storage temp.   room temp
SMILES string   CN1CCCC1=O
InChI   1S/C5H9NO/c1-6-4-2-3-5(6)7/h2-4H2,1H3



1-Methyl-2-pyrrolidinone may be used as a solvent in the following processes:
• Preparation of 2-aryl and 2-alkyl benzothiazoles.
• Ullmann coupling reaction of aryl halides and phenols to form Ullmann ethers in the presence of 2,2,6,6-tetramethylheptane-3,5-dione.
• Stille cross-coupling reaction of aryl iodides with organostannanes catalyzed by Pd/C in the presence of copper iodide as cocatalyst.


1, 6×1, 2, 4×2 L in Sure/Seal™

18 L in Pure-Pac™ 1

View returnable container options.

100, 12×100 mL in Sure/Seal™

50 L in Pure-Pac™ 2

Other Notes

Pure-Pac® II containers require the Micromatic MacroValve coupler for dispensing solvents, Z560723.

Legal Information

Pure-Pac is a registered trademark of Sigma-Aldrich Co. LLC

Safety & Documentation

Safety Information

Signal word 
Hazard statements 
Target organs 
Respiratory system
WGK Germany 
Flash Point(F) 
195.8 °F - Pensky-Martens closed cup
Flash Point(C) 
91 °C - Pensky-Martens closed cup


Certificate of Analysis (COA)

Please Enter a Lot Number

Certificate of Origin (COO)

Please Enter a Lot Number
Protocols & Articles


Anhydrous Solvents for Coupling Reactions

Due to the sensitivity to air and moisture, coupling reactions often require relatively low air and water conditions to initiate the reaction. Therefore, the use of anhydrous solvents is highly recom...
Keywords: Coupling reactions, Cross couplings, Negishi Coupling, Solvents

Anhydrous Solvents for Organic and Organometallic Chemistry

Many well-known reactions require water-free conditions to initiate or complete the reaction. Failure to include anhydrous solvents can result in low product yield or reaction failure. As the market ...
Keywords: Acylations, Alkylations, Electrophilic aromatic substitution, Formylations, Grignard Reaction, Solvents, Substitutions, Vilsmeier-Haack reaction

Inorganic Graphene Analogues

Nanomaterials have steadily established their presence in day to-day life owing to their many-fold efficiency over bulk materials and due to the advancements in processing that have rendered them rem...
Keywords: Adsorption, Asymmetric synthesis, Centrifugation, Chemical vapor deposition, Deposition, Electronics, Environmental, Filtration, Homogenization, Metal organic frameworks, Nanomaterials, Nanotubes, Nucleic acid annealing, Oxidations, Positron Emission Tomography, Printed electronics, Semiconductor, Separation, Solar cells, Solvents, Spin coating

Pressure-Temperature Calculator for Solvents

*Calculations provide estimated results based on Antoine's Coefficients and their associated temperature range values. Antoine's Coefficients were obtained from the National Institute of Standards an...

The First Negishi Cross-Coupling Reaction of Two Alkyl Centers Utilizing a Pd-N-Heterocyclic Carbene (NHC) Catalyst

The development of an NHC-based system capable of cross-coupling sp3-sp3 centers in high yield has been a long-standing challenge. This communication describes the use of a Pd-NHC catalytic system th...
Keywords: Catalysis, Chromatography, Cross couplings, Flash chromatography

Peer-Reviewed Papers


Related Products

also commonly purchased with this product

Product #


Add to Cart

271012 N,N-Dimethylacetamide, anhydrous, 99.8%
182702 Poly(vinylidene fluoride), average Mw ~534,000 by GPC, powder
401757 Tetrahydrofuran, anhydrous, ≥99.9%, inhibitor-free
227056 N,N-Dimethylformamide, anhydrous, 99.8%
Z163600 MiniPax® absorbent packets, molecular sieves, weight 0.5 g (desiccant), L × W 5/8  in. × 1 1/16  in.


Product #


Add to Cart

Z108812 Zerostat anti-static instrument, keeps film, glass, and plasticware dust and lint-free

Technical Service:

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Bulk Ordering & Pricing:

Need larger quantities for your development, manufacturing or research applications?