• USA Home
  • 673277 - 2-Methyltetrahydrofuran

673277 Sigma-Aldrich

2-Methyltetrahydrofuran Green Alternative

anhydrous, ≥99%, Inhibitor-free

Synonym: 2-MeTHF, Tetrahydro-2-methylfuran, Tetrahydrosilvan

  • CAS Number 96-47-9

  • Empirical Formula (Hill Notation) C5H10O

  • Molecular Weight 86.13

  •  Beilstein Registry Number 102448

  •  EC Number 202-507-4

  •  MDL number MFCD00005367

  •  PubChem Substance ID 57652076



Related Categories Anhydrous Solvents, Building Blocks, C4 to C7, Chemical Synthesis, Furans,
grade   anhydrous
assay   ≥99%
expl. lim.   0.34—6.3 % ((lit.))
greener alternative product characteristics   Safer Solvents and Auxiliaries
Learn more about the Principles of Green Chemistry.
impurities   ≤0.002% water
  ≤0.005% water (100 mL pkg)
evapn. residue   ≤0.0003%
refractive index   n20/D 1.406(lit.)
bp   78-80 °C(lit.)
mp   -136 °C (lit.)
density   0.86 g/mL at 25 °C(lit.)


Features and Benefits

Greener alternative for THF, DCM, DMSO, and MTBE


1, 2 L in Sure/Seal™

100, 12×100 mL in Sure/Seal™

200 L in Pure-Pac™ 2


2-Methyltetrahydrofuran may be used as solvent for phosphatidylserine synthesis.
It may be used as an alternative solvent to:
• Dimethyl sulfoxide (DMSO) or methyl tert-butyl ether (MTBE) in the C-C bond forming reactions catalyzed by lyase enzyme.
• Tetrahydrofuran (THF) in the reaction between Grignard reagents and carbonyl compounds.
• Methylene chloride in some biphasic reactions.

Green Alternatives to DCM and THF from Renewable resources

2-Methyltetrahydrofuran (2-MeTHF): A Biomass-Derived Solvent with Broad Application in Organic Chemistry

General description

2-Methyltetrahydrofuran (2-MTHF), a 2-methyl substituted tetrahydrofuran, is a biomass derived solvent. It is a potential greener solvent alternative for organic synthesis. It shows resistance to reduction by lithium making it a promising candidate as electrolytes in lithium batteries. Its polarity and Lewis base strength is intermediate between tetrahydrofuran (THF) and diethyl ether. The ring opening reaction of 2-MTHF has been studied using acid chloride and iodide.

Safety & Documentation

Safety Information

Signal word 
Hazard statements 
Supplemental Hazard Statements 
May form explosive peroxides.
UN 2536 3 / PGII
WGK Germany 
Flash Point(F) 
14 °F
Flash Point(C) 
-10 °C

Meet Synthia - Retrosynthesis Sofware
Protocols & Articles


Pressure-Temperature Calculator for Solvents

*Calculations provide estimated results based on Antoine's Coefficients and their associated temperature range values. Antoine's Coefficients were obtained from the National Institute of Standards an...

Related Content

Greener Alternatives Three Categories

A new icon has been added to identify our Greener alternative products. Products with this icon fulfill one of the three criteria.
Keywords: Alternative energy, Ceramics, Environmental, Green chemistry, Materials Science, Nanomaterials, PAGE

Pressure-Temperature Nomograph Interactive Tool

The Pressure-Temperature Nomograph tool is an application of the Clausius-Clapeyron Equation, which assumes the heat of vaporization is a constant over a pressure range. Antoine´s Equation gets aroun...
Keywords: Evaporation, Vaporization

Properties of Solvents Table

a. Gant, R., LC/GC 10 (7), 515 (1992) 1. At 20 °C 2. At 20 °C +/- 5 °C relative to water at 4 °C 3. At 10 mmHg pressure 4. At l=589.32 nm
Keywords: Gas chromatography, High performance liquid chromatography

Peer-Reviewed Papers


Related Products

Technical Service:

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Bulk Ordering & Pricing:

Need larger quantities for your development, manufacturing or research applications?