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75890 Sigma-Aldrich

α-Ketoglutaric acid

99.0-101.0% (T)

Synonym: 2-Oxoglutaric acid, 2-Oxopentanedioic acid, alpha-Ketoglutarate, alpha-Ketoglutaric acid

  • CAS Number 328-50-7

  • Linear Formula HOOCCH2CH2COCOOH

  • Molecular Weight 146.10

  •  Beilstein Registry Number 1705689

  •  EC Number 206-330-3

  •  MDL number MFCD00004165

  •  PubChem Substance ID 329766750

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Properties

Related Categories Building Blocks, C1 to C5, Carbonyl Compounds, Carboxylic Acids, Chemical Synthesis,
InChI Key   KPGXRSRHYNQIFN-UHFFFAOYSA-N
Quality Level   PREMIUM
assay   99.0-101.0% (T)
mp   114-118 °C
solubility   H2O: 1 g/10 mL, clear to slightly hazy, colorless to almost colorless
storage temp.   2-8°C

Description

Other Notes

Reagent for the analysis of tryptophan; Substrate for glutamate dehydrogenase

Application

α-ketoglutaric acid along with L-arginine can undergo reduction with sodium cyanoborohydride to form the diastereomers, nopaline and isonopaline.

General description

α-Ketoglutaric acid is a 2-oxocarboxylic acid (2-OCA) that is formed as a metabolite in the Kreb′s cycle.

Safety & Documentation

Safety Information

Symbol 
GHS05  GHS05
Signal word 
Danger
Hazard statements 
Precautionary statements 
Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
3

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Protocols & Articles

Articles

Citric Acid Cycle, TCA or Krebs Cycle

Acetyl-CoA enters a cycle whose discovery by Hans Krebs 70 years ago marked a milestone in biochemistry. The citric acid cycle is also termed the tricarboxylic acid cycle, TCA cycle or Krebs cycle (s...
BioFiles 2007, 2.6, 16.
Keywords: Addition reactions, Biochemistry, Catalysis, Citric Acid Cycle, Decarboxylations, Dehydration reaction, Hydration reaction, Metabolites, Oxidations, Phosphorylations

Peer-Reviewed Papers
15

References

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