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75890 Sigma-Aldrich

α-Ketoglutaric acid

99.0-101.0% (T)

Synonym: 2-Oxoglutaric acid, 2-Oxopentanedioic acid, alpha-Ketoglutarate, alpha-Ketoglutaric acid

  • CAS Number 328-50-7

  • Linear Formula HOOCCH2CH2COCOOH

  • Molecular Weight 146.10

  •  Beilstein/REAXYS Number 1705689

  •  EC Number 206-330-3

  •  MDL number MFCD00004165

  •  PubChem Substance ID 329766750

  •  NACRES NA.22

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Properties

Related Categories Building Blocks, C1 to C5, Carbonyl Compounds, Carboxylic Acids, Chemical Synthesis,
InChI Key   KPGXRSRHYNQIFN-UHFFFAOYSA-N
Quality Level   300
assay   99.0-101.0% (T)
mp   114-118 °C
solubility   H2O: 1 g/10 mL, clear to slightly hazy, colorless to almost colorless
storage temp.   2-8°C

Description

General description

α-Ketoglutaric acid is a 2-oxocarboxylic acid (2-OCA) that is formed as a metabolite in the Kreb′s cycle.

Application

α-ketoglutaric acid along with L-arginine can undergo reduction with sodium cyanoborohydride to form the diastereomers, nopaline and isonopaline.

Other Notes

Reagent for the analysis of tryptophan; Substrate for glutamate dehydrogenase

Safety & Documentation

Safety Information

Symbol 
GHS05  GHS05
Signal word 
Danger
Hazard statements 
Precautionary statements 
Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis (COA)

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Protocols & Articles

Articles

The Krebs cycle — harnessing chemical energy for cellular respiration

The tricarboxylic acid (TCA) cycle, also known as the Krebs or citric acid cycle, is the main source of energy for cells and an important part of aerobic respiration. The cycle harnesses the availabl...
Keywords: Addition reactions, Aerobic, Biochemistry, Catalysis, Citric Acid Cycle, Decarboxylations, Dehydration reaction, Diseases, Enzyme activity, Glycolysis, Hydration reaction, Lipid Metabolism, Mass spectrometry, Metabolism, Metabolites, Metabolomics, Oxidations, Phosphorylations, Respiration

Peer-Reviewed Papers
15

References

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