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82475 Sigma-Aldrich

Prostaglandin E2

≥99.0% (TLC)

Synonym: (5Z,11α,13E,15S)-11,15-Dihydroxy-9-oxoprosta-5,13-dienoic acid, Dinoprostone, PGE2

  • CAS Number 363-24-6

  • Empirical Formula (Hill Notation) C20H32O5

  • Molecular Weight 352.47

  •  Beilstein Registry Number 4709356

  •  EC Number 206-656-6

  •  MDL number MFCD00077861

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Properties

InChI Key   XEYBRNLFEZDVAW-ARSRFYASSA-N
assay   ≥99.0% (TLC)
solubility   acetone: 10 mg/mL, clear, colorless to faintly yellow
storage temp.   −20°C

Description

Other Notes

Differential effect of PGE2 on transforming growth factor-β, and insulin-induced collagen formation in lung fibroblasts

Biochem/physiol Actions

Most biologically active prostaglandin. PGE2 induces cervical ripening and parturition; mediates bradykinin-induced vasodilation; regulates adenylyl cyclase. Tumor cells that over-express cyclooxygenase 2 display increased invasiveness, angiogenesis, and resistance to apoptosis that may be due to the PGE2-induced expression of angiogenic factors and stabilization of the anti-apoptotic protein, survivin.The effect of PGE2 on the immune system is mixed. It inhibits T cell activation in vitro, suggesting it is an immunosuppressant. However, in vivo, it appears to effect expansion of the Th17 subset and differentiation of the Th1 subset of T helper cells, marking it as an immunoactivator.

Safety & Documentation

Safety Information

Symbol 
Signal word 
Danger
Hazard statements 
Precautionary statements 
RIDADR 
NONH for all modes of transport
WGK Germany 
3
RTECS 
UK8000000

Documents

Certificate of Analysis

Protocols & Articles
Peer-Reviewed Papers
15

References

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