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94837 Sigma-Aldrich

(±)-Verapamil hydrochloride

≥99.0% (TLC)

Synonym: 5-[N-(3,4-Dimethoxyphenylethyl)methylamino]-2-(3,4-dimethoxyphenyl)-2-isopropylvaleronitrile hydrochloride

  • CAS Number 152-11-4

  • Linear Formula (CH3O)2C6H3CH2CH2N(CH3)(CH2)3C[C6H3(OCH3)2][CH(CH3)2]CN · HCl

  • Molecular Weight 491.06

  •  Beilstein Registry Number 3647093

  •  EC Number 205-800-5

  •  MDL number MFCD00055208

  •  PubChem Substance ID 24890064

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Properties

InChI Key   DOQPXTMNIUCOSY-UHFFFAOYSA-N
assay   ≥99.0% (TLC)
mp   142 °C (dec.) (lit.)
solubility   methanol: 50 mg/mL, clear, colorless

Description

Biochem/physiol Actions

α1-adrenoceptor antagonist; L-type calcium channel blocker. Blocks L-type Ca2+ channels in smooth and cardiac muscle, induces apoptosis of human primary and metastatic colon adenocarcinoma cells in vitro. Drug resistance reversal agent acting on Pgp, e.g. decrease renal tubule elimination of digoxin. Increases basal ATPase activity of Pgp. Substrate of Cyp3A4 and CYP2C6.

Safety & Documentation

Safety Information

Symbol 
Signal word 
Danger
Hazard statements 
Precautionary statements 
RIDADR 
UN2811 - class 6.1 - PG 3 - EHS - Toxic solids, organic, n.o.s., HI: all
WGK Germany 
3
RTECS 
YV8320000

Documents

Certificate of Analysis

Protocols & Articles
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V4629 (±)-Verapamil hydrochloride, ≥99% (titration), powder

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