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H7753 Sigma-Aldrich

Hexestrol

analytical standard

Synonym: 4,4′-(1,2-Diethylethylene)diphenol, meso-3,4-Bis(4-hydroxyphenyl)hexane, Dihydrodiethylstilbestrol

  • CAS Number 84-16-2

  • Empirical Formula (Hill Notation) C18H22O2

  • Molecular Weight 270.37

  •  Beilstein Registry Number 3209460

  •  EC Number 201-518-1

  •  MDL number MFCD00068996

  •  PubChem Substance ID 329815246

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Properties

Related Categories Additional Drugs, Additional Standards, Analytical Standards, Analytical/Chromatography, Chromatography,
grade   analytical standard
InChI Key   PBBGSZCBWVPOOL-HDICACEKSA-N
assay   ≥98%
form   neat
application(s)   HPLC: suitable
  gas chromatography (GC): suitable
format   neat
Gene Information   human ... ESR1(2099)
rat ... Esr1(24890)

Description

Biochem/physiol Actions

The carcinogen hexestrol is a nonsteroidal synthetic estrogen. Metabolic activation of hexestrol to its quinone, which reacts with DNA to form analogous depurinating adducts, may be a primary critical event leading to oncogenic mutations and cancer initiation.

Linkage

Reduced analogue of diethylstilbestrol.

Packaging

1, 5 g in poly bottle

Application

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Safety & Documentation

Safety Information

Symbol 
GHS08  GHS08
Signal word 
Danger
Hazard statements 
Precautionary statements 
RIDADR 
NONH for all modes of transport
WGK Germany 
2
RTECS 
SL0560850

Documents

Certificate of Analysis

Certificate of Origin

Protocols & Articles

Articles

DNA Damage and Repair

Damage to cellular DNA is involved in mutagenesis and the development of cancer. The DNA in a human cell undergoes several thousand to a million damaging events per day, generated by both external (e...
Keywords: AGE, Alkylations, Apoptosis, Biochemistry, Cancer, Carcinogens, Catalysis, Clinical, DNA replication, Deaminations, Degradations, Eliminations, Environmental, Enzymology, Gene expression, Genetic, Infrared spectroscopy, Metabolites, Methylations, Mutagens, Oncology, Oxidations, Polymorphisms, Rearrangements, Recombination, Substitutions, Transcription, transformation

TLC Analysis of Anabolic Compounds on HPTLC DIOL F254s (analyte set 1)

From our library of Articles, Sigma-Aldrich presents TLC Analysis of Anabolic Compounds on HPTLC DIOL F254s (analyte set 1)
Keywords: Clinical, Thin layer chromatography

Peer-Reviewed Papers
15

References

Related Products

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