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P5629 Sigma-Aldrich

Potassium phosphate tribasic

reagent grade, ≥98%

Synonym: Tripotassium phosphate



Related Categories Biochemicals and Reagents, Biological Buffers, Buffers A to Z, Chemical Synthesis, Inorganic Salts,
Quality Level   200
grade   reagent grade
assay   ≥98%
form   powder
pH   11.9 (25 °C, 10 g/L)
solubility   water: 100 mg/mL, clear, colorless
density   2.564 g/mL at 25 °C (lit.)
storage temp.   room temp
SMILES string   [K].OP(O)(O)=O
InChI   1S/3K.H3O4P/c;;;1-5(2,3)4/h;;;(H3,1,2,3,4)/q3*+1;/p-3


General description

Potassium phosphate tribasic exhibits high catalytic property in trans esterification reactions. It has bactericidal activity.


Potassium phosphate tribasic has been used:
• in lysis buffer for the isolation of protein from Gram positive bacteria
• as a reagent for the scalable synthesis and post-modification of NU-1000 (mesoporous metal-organic framework)
• as a reagent for the plasma membrane preparation of Lilium davidii or Oryza sativa with high purity


1 kg in poly bottle

10 kg in poly drum

25, 500 g in poly bottle

Safety & Documentation

Safety Information

Signal word 
Hazard statements 
Target organs 
Respiratory system
Personal Protective Equipment 
NONH for all modes of transport
WGK Germany 


Certificate of Analysis (COA)

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Certificate of Origin (COO)

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Buffers - From Bnech to Bulk
Protocols & Articles


A New Biarylphosphine Ligand for the Pd-Catalyzed Synthesis of Diaryl Ethers under Mild Conditions

An efficient, general palladium catalyst for C-O bond-forming reactions of secondary and primary alcohols with a range of aryl halides has been developed using the ligand�1. Heteroaryl halides, and f...
Keywords: Chromatography, Flash chromatography, Ligands

A New Palladium Precatalyst Allows for the Fast Suzuki-Miyaura Coupling Reactions of Unstable Polyfluorophenyl and 2-Heteroaryl Boronic Acids

A method for the Pd-catalyzed coupling of 2-aminothiazole derivatives with aryl bromides and triflates is described. Significantly, for this class of nucleophiles, the coupling exhibits a broad subst...
Keywords: Catalysis, Chromatography

A Versatile Method for Suzuki Cross-Coupling Reactions of Nitrogen Heterocycles

In air, Pd(OAc)2 (9.1 mg, 1.141 mmol), PCy3 (22.4 mg, 1.181 mmol), and K3PO4�H2O (276 mg, 1.21 mmol) are added to a reaction vessel equipped with a stir bar. The vessel is sealed with a septum and pu...
Keywords: Chromatography, Column chromatography

Catalyst-Controlled Chemoselective Arylation of 2-Aminobenzimidazoles-

Pd2(dba)3/tris(tert-butyl)�HBF4/KF�2H2O serves as a mild, robust, and user-friendly method for the efficient Suzuki cross-coupling of a diverse array of aryl and heteroaryl halides with aryl- and het...
Keywords: Chromatography, Cross couplings, Flash chromatography

Copper-Free Sonogashira Coupling of Cyclopropyl Iodides with Terminal Alkynes

An efficient palladium-catalyzed cyanation of aryl chlorides is established. In the presence of a highly effective Pd/CM-phos catalyst, cyanation of aryl chlorides proceeds at 71 �C in general, which...
Keywords: Catalysis, Chromatography, Column chromatography, Gas chromatography, Ligands, Nuclear magnetic resonance spectroscopy

Cross-Coupling of Mesylated Phenol Derivatives with Potassium Cyclopropyltrifluoroborate

A robust and efficient protocol for the introduction of the dioxolanylethyl moiety onto various aryl and heteroaryl halides has been developed, providing cross-coupling yields up to 93%. Copper-catal...
Keywords: Catalysis, Chromatography, Cross couplings, Flash chromatography, Purification

Design and preparation of new palladium precatalysts for C-C and C-N cross-coupling reactions

Good to excellent yields�of aryl trifluoromethyl sulfides, which are an important class of compounds in both the pharmaceutical and agrochemical areas, can be achieved under mild conditions by the Pd...
Keywords: Agrochemicals, Catalysis, Pharmaceutical

First cross-coupling reactions on halogenated 1H-1,2,4-triazole nucleosides

C-O activation of mesylates by a palladium catalyst and subsequent cross-coupling with potassium cyclopropyltrifluoroborate have been achieved with high yield. Both electron-enriched and electron- de...
Keywords: Chromatography, Cross couplings

Ligand-Controlled Palladium-Catalyzed Regiodivergent Suzuki- Miyaura Cross-Coupling of Allylboronates and Aryl Halides-

Pd-PEPPSI-IPent has proven to be an excellent catalyst for the Negishi cross-coupling reaction of secondary alkylzinc reagents with a wide variety of aryl/heteroaryl halides. Importantly, b-hydride e...
Keywords: Chromatography, Coupling reactions, Cross couplings, Eliminations, Flash chromatography, Ligands, Nuclear magnetic resonance spectroscopy, Purification

Pd-Catalyzed Alkynylation of 2-Chloroacetates and 2-Chloroacetamides with Potassium Alkynyltrifluoroborates

A practical method for palladium-catalyzed cyanation of aryl halides using Pd/C is described. The new method can be applied to a variety of aryl bromide and active aryl chloride substrates to effect ...
Keywords: Catalysis, Chromatography, High performance liquid chromatography

Room-Temperature Alkyl-Alkyl Suzuki Cross-Coupling of Alkyl Bromides that Possess -- Hydrogens

The trifluoromethyl group can dramatically influence the properties of organic molecules, thereby increasing their applicability as pharmaceuticals, agrochemicals, or building blocks for organic mate...
Keywords: Agrochemicals, Building blocks, Catalysis, Pharmaceutical, transformation

Suzuki-Miyaura Cross-Coupling of Unprotected, Nitrogen-Rich Heterocycles: Substrate Scope and Mechanistic Investigation

A mild, efficient, and low-temperature palladium-catalyzed cyanation of (hetero)aryl halides and triflates is reported. Previous palladium-catalyzed cyanations of (hetero)aryl halides have required h...
Keywords: Catalysis, Chromatography, Flash chromatography, Thin layer chromatography

Synthesis and Application of Palladium Precatalysts that Accommodate Extremely Bulky Di-tert-butylphosphino Biaryl Ligands

An umpolung approach to the synthesis of diaryl ketones has been developed based on in situ generation of acyl anion equivalents and their catalytic arylation. This method entails the base-promoted, ...
Keywords: Arylations, Catalysis, Chromatography, Cross couplings, Flash chromatography

Related Content

BioUltra Biological Buffers

A buffer, as defined by Van Slyke [1], is "a substance which by its presence in solution increases the amount of acid or alkali that must be added to cause unit change in pH". Buffers are thus very i...
Keywords: Absorption, Adsorption, Biochemistry, Biological Buffers, Biological processes, Buffers, PAGE

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