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201030 Sigma-Aldrich

Osmium tetroxide

ReagentPlus®, 99.8%

Synonym: ‘Osmic acid’, Osmium(VIII)-oxide

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Properties

Related Categories Chemical Synthesis, Materials Science, Metal and Ceramic Science, Osmium, Oxides,
Quality Level   200
grade   ReagentPlus®
vapor density   8.8 (vs air)
vapor pressure   7 mmHg ( 20 °C)
InChI Key   VUVGYHUDAICLFK-UHFFFAOYSA-N
assay   99.8%
form   crystalline
  powder
bp   130 °C (lit.)
mp   39.5-41 °C (lit.)
storage temp.   2-8°C

Description

General description

Osmium tetroxide (OsO4) is widely employed as a catalyst in various organic reactions. Stereochemical aspects of the OsO4 assisted oxidation of allylic alcohols and their derivatives have been reported. Its reaction with olefins has been investigated. It participates as a catalyst for oxidizing fluoroquinolones, via reaction with potassium hexacyanoferrate(III) in alkaline medium. Kinetics of this oxidation reaction was studied.

Application

Osmium tetroxide may be employed as a catalyst for the hydroxylation of sterically hindered olefins.

Osmium tetroxide may be used in the following processes:
• To promote the lactonization of alkenols to lactones.
• To mediate the selective oxidative cleavage of olefins by oxone to form the corresponding ketones or carboxylic acids.
• Dihydroxylation of mono-trans-di, and trisubstituted olefins to form 1,2-diols with high enantioselectivity in the presence of chiral amines.

Widely used oxidizer for visualizing cells in microscopy. Promotes oxidative cleavage of graphene layers in carbon nanotubes creating the possibility of opening ′windows′ in fullerene cages.

Packaging

1 g in ampule

250, 500 mg in ampule

Legal Information

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Safety & Documentation

Safety Information

Symbol 
Signal word 
Danger
Hazard statements 
RIDADR 
UN 2471 6.1 / PGI
WGK Germany 
1
RTECS 
RN1140000

Documents

Certificate of Analysis (COA)

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Certificate of Origin (COO)

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Protocols & Articles
Peer-Reviewed Papers
15

References

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