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223387 Sigma-Aldrich

Nickel(II) chloride hexahydrate

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Properties

Related Categories Essential Chemicals, Nickel Salts, Research Essentials, Salts
Quality Level   100
product line   ReagentPlus®
assay   23.0-26.0% Ni basis (EDTA titration)
form   powder or crystals
SMILES string   [H]O[H].[H]O[H].[H]O[H].[H]O[H].[H]O[H].[H]O[H].Cl[Ni]Cl
InChI   1S/2ClH.Ni.6H2O/h2*1H;;6*1H2/q;;+2;;;;;;/p-2
InChI key   LAIZPRYFQUWUBN-UHFFFAOYSA-L

Description

General description

Nickel(II) chloride hexahydrate is a hydrated nickel salt. Its crystals were monoclinc and crystal structure was investigated by X-ray single crystal method.

Application

Nickel(II) chloride hexahydrate may be employed as a catalyst in the high yield synthesis of tetra-substituted pyrrole derivatives. It may be used for the conversion of tetrahydropyranyl (THP) and tert-butyldimethylsilyl (TBS) ethers to the corresponding hydroxyl compounds.

Nickel(II) chloride hexahydrate may be used as a catalyst in the following processes:
• Synthesis of tetra-substituted pyrrole derivatives via four-component condensation reaction of aromatic aldehydes, benzylamines, β-ketoesters and nitroalkanes.
• In combination with 1,2-ethanedithiol for the deprotection of tetrahydropyranyl (THP) and tert-butyldimethylsilyl (TBS) ethers to their corresponding hydroxyl compounds.
• Synthesis of 3,4-dihydropyrimidinones from aldehydes and β-keto esters via Biginelli condensation.

Packaging

2 kg in poly bottle

25, 500 g in poly bottle

Legal Information

ReagentPlus is a registered trademark of Sigma-Aldrich Co. LLC

Safety & Documentation

Safety Information

Symbol 
Signal word 
Danger
Target organs 
Lungs
RIDADR 
UN3288 - class 6.1 - PG 3 - EHS - RQ - Toxic solid, inorganic, n.o.s., HI: all
WGK Germany 
WGK 3
RTECS 
QR6480000
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Certificate of Origin (COO)

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Protocols & Articles
Peer-Reviewed Papers
15

References

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