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34865 Sigma-Aldrich

Tetrahydrofuran

inhibitor-free, for HPLC, ≥99.9%

Synonym: Butylene oxide, Oxolane, THF, Tetramethylene oxide

  • CAS Number 109-99-9

  • Empirical Formula (Hill Notation) C4H8O

  • Molecular Weight 72.11

  •  Beilstein/REAXYS Number 102391

  •  EC Number 203-726-8

  •  MDL number MFCD00005356

  •  PubChem Substance ID 329755073

  •  NACRES NA.21

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Properties

Related Categories Analytical Reagents, Analytical/Chromatography, Chromatography Reagents & Solvents, HPLC Plus Grade Solvents, HPLC Solvents,
Quality Level   100
grade   for HPLC
vapor density   2.5 (vs air)
vapor pressure   114 mmHg ( 15 °C)
  143 mmHg ( 20 °C)
InChI Key   WYURNTSHIVDZCO-UHFFFAOYSA-N
assay   ≥99.9%
autoignition temp.   610 °F
expl. lim.   1.8-11.8 %
impurities   ≤0.0005% non-volatile matter
  ≤0.002% free acid (as CH3COOH)
  ≤0.05% peroxides (as H2O2)
  ≤0.05% water (Karl Fischer)
evapn. residue   ≤0.0005%
color   APHA: ≤10
refractive index   n20/D 1.407 (lit.)
bp   65-67 °C (lit.)
mp   −108 °C (lit.)
density   0.889 g/mL at 25 °C (lit.)
absorption   ≤0.0044 at 315 nm
  ≤0.005 at 350 nm
  ≤0.005 at 400 nm
  ≤0.02 at 300 nm
  ≤0.046 at 275 nm
  ≤0.18 at 250 nm
  ≤0.26 at 245 nm
  ≤1.0 at 212 nm
UV absorption   λ: 245 nm Amax: ≤0.26
  λ: 275 nm Amax: ≤0.046
  λ: 315 μm Amax: ≤0.0044
suitability   complies for IR spectroscopy
Featured Industry   Food and Beverages

Description

General description

Tetrahydrofuran (THF) is widely employed as a solvent. It constitutes the key fragment of various natural products (polyether antibiotics). THF forms a double hydrate with hydrogen sulfide. Crystal structure of this double hydrate has been investigated by three-dimensional single-crystal studies. Butane-1,4-diol is formed as an intermediate during the synthesis of THF. Hot THF is useful for the dissolution of polyvinylidene chloride (PVDV).

Application

Suitable for HPLC, spectrophotometry, environmental testing

Tetrahydrofuran may be used for the dissolution of poly-ε-caprolactone (PCL) and 1,3-diaminopentane, during the preparation of poly-ε-caprolactone (PCL)-hydroxyapatite (HA) scaffolds and acrylate-terminated poly(5-amino-1-pentanol-co-1,4-butanediol diacrylate) (C32)- 1,3-diaminopentane (117) polymer, respectively.

Packaging

1, 6×1, 2, 4×2.5, 4, 4×4 L in glass bottle

20 L in Nowpak™

100, 12×100 mL in glass bottle

200 L in Pure-Pac™ 1

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Safety & Documentation

Safety Information

Symbol 
Signal word 
Danger
Hazard statements 
Supplemental Hazard Statements 
May form explosive peroxides.
RIDADR 
UN 2056 3 / PGII
WGK Germany 
1
RTECS 
LU5950000
Flash Point(F) 
1.4 °F
Flash Point(C) 
-17 °C

Documents

Certificate of Analysis (COA)

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Certificate of Origin (COO)

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Dispensette™ S
Protocols & Articles

Articles

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From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Acrylic Resin on TSKgel® SuperµLtiporeHZ-M vs. TSKgel® SuperHZ
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HPLC Analysis of Polar Compounds on Ascentis® Express RP-Amide Particles

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Polar Compounds on Ascentis® Express RP-Amide Particles
Keywords: Chromatography, High performance liquid chromatography, Pharmaceutical

HPLC Analysis of Various Polymers on TSKgel® SuperµLtiporeHZ-H

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Various Polymers on TSKgel® SuperµLtiporeHZ-H
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Pressure-Temperature Calculator for Solvents

*Calculations provide estimated results based on Antoine's Coefficients and their associated temperature range values. Antoine's Coefficients were obtained from the National Institute of Standards an...

Peer-Reviewed Papers
15

References

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